Extremely selective, non-peptide NPY Y5
receptor antagonist. Displays > 1000-fold selectivity over Y1
values are 1.4, 2765, 7187 and 5637 nM at cloned rat Y5
receptors respectively. Potently inhibits NPY-induced food intake following i.p. administration in diabetic, free-feeding and fasted rats.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y5 receptor.
Criscione et al.
Potent and selective tools to investigate neuropeptide Y receptors in the central and peripheral nervous systems: BIB03304 (Y1) and CGP71683A (Y5).
Dumont et al.
Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea-pig.
Lecklin et al.
The citations listed below are publications that use Tocris products. Selected citations for CGP 71683 hydrochloride include:
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