Catalog Number: 2199
Chemical Name: N-[[trans-4-[[(4-Amino-2-quinazolinyl)amino]methyl]cyclohexyl]methyl]-1-naphthalenesulfonamide hydrochloride
Biological Activity
Extremely selective, non-peptide NPY Y5 receptor antagonist. Displays > 1000-fold selectivity over Y1, Y2 and Y4 receptors; IC50 values are 1.4, 2765, 7187 and 5637 nM at cloned rat Y5, Y1, Y2 and Y4 receptors respectively. Potently inhibits NPY-induced food intake following i.p. administration in diabetic, free-feeding and fasted rats.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y5 receptor.
    Criscione et al.
    J.Clin.Invest., 1998;102:2136
  2. Potent and selective tools to investigate neuropeptide Y receptors in the central and peripheral nervous systems: BIB03304 (Y1) and CGP71683A (Y5).
    Dumont et al.
    Can.J.Physiol.Pharmacol., 2000;78:116
  3. Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea-pig.
    Lecklin et al.
    Br.J.Pharmacol., 2002;135:2029
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