CGP 71683 hydrochloride

Tocris Bioscience | Catalog # 2199

Highly selective and potent non-peptide NPY Y5 receptor antagonist
Tocris Bioscience

Key Product Details

Description

Highly selective and potent non-peptide NPY Y5 receptor antagonist
View all NPY Receptor Antagonists »

Product Description

CGP 71683 hydrochloride is an extremely selective, non-peptide NPY Y5 receptor antagonist. Displays > 1000-fold selectivity over Y1, Y2 and Y4 receptors; IC50 values are 1.4, 2765, 7187 and 5637 nM at cloned rat Y5, Y1, Y2 and Y4 receptors respectively. Potently inhibits NPY-induced food intake following i.p. administration in diabetic, free-feeding and fasted rats.

Product Specifications for CGP 71683 hydrochloride

Molecular Weight

512.07

Formula

C26H29N5O2S.HCl

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-[[trans-4-[[(4-Amino-2-quinazolinyl)amino]methyl]cyclohexyl]methyl]-1-naphthalenesulfonamide hydrochloride

CAS Number

192322-50-2

PubChem ID

9849276

InChI Key

DIQDKUNCSVFGHH-UHFFFAOYSA-N

SMILES

NC1=NC(NC[C@H]3CC[C@H](CNS(=O)(C4=CC=CC5=C4C=CC=C5)=O)CC3)=NC2=C1C=CC=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.21 100

Preparing Stock Solutions for CGP 71683 hydrochloride

The following data is based on the product molecular weight 512.07.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.95 mL 9.76 mL 19.53 mL
5 mM 0.39 mL 1.95 mL 3.91 mL
10 mM 0.20 mL 0.98 mL 1.95 mL
50 mM 0.04 mL 0.20 mL 0.39 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

Product Documents for CGP 71683 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CGP 71683 hydrochloride

For research use only

Related Research Areas

Nutrition and Appetite
Obesity

Citations for CGP 71683 hydrochloride

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