CGP 71683 hydrochloride

  ( 6 citations )    
Product Datasheet
Catalog Number:2199
Chemical Name:N-[[trans-4-[[(4-Amino-2-quinazolinyl)amino]methyl]cyclohexyl]methyl]-1-naphthalenesulfonamide hydrochloride
Product Details
Citations (6)
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Reviews
Biological Activity
Extremely selective, non-peptide NPY Y5 receptor antagonist. Displays > 1000-fold selectivity over Y1, Y2 and Y4 receptors; IC50 values are 1.4, 2765, 7187 and 5637 nM at cloned rat Y5, Y1, Y2 and Y4 receptors respectively. Potently inhibits NPY-induced food intake following i.p. administration in diabetic, free-feeding and fasted rats.
Technical Data
  • M.Wt:
    512.07
  • Formula:
    C26H29N5O2S.HCl
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Desiccate at +4°C
  • CAS No:
    192322-50-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for CGP 71683 hydrochloride include:

6 Citations: Showing 1 - 6
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  1. Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects.
    Authors: Tilan Et al.
    Oncotarget  2013;4:2487
  2. Role of peptide YY(3-36) in the satiety produced by gastric delivery of macronutrients in rats.
    Authors: Reidelberger Et al.
    Am J Physiol Endocrinol Metab  2013;304:E944
  3. Stress hormone epinephrine enhances adipogenesis in murine embryonic stem cells by up-regulating the neuropeptide Y system.
    Authors: Han Et al.
    PLoS One  2012;7:e36609
  4. Deconstruction of a neural circuit for hunger.
    Authors: Atasoy Et al.
    Am J Physiol Cell Physiol  2012;488:172
  5. Neuropeptide Y inhibits cholangiocarcinoma cell growth and invasion.
    Authors: Demorrow Et al.
    Nature  2011;300:C1078
  6. Dipeptidyl peptidases as survival factors in Ewing sarcoma family of tumors: implications for tumor biology and therapy.
    Authors: Lu Et al.
    J Biol Chem  2011;286:27494

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