Catalog Number: 1161
Alternate Names: Calcitonin Gene-Related Peptide (rat)
Biological Activity
Endogenous neuropeptide; potent vasodilator which also exerts cardiovascular, pro-inflammatory and metabolic effects.
Technical Data
  • M.Wt:
    3807
  • Formula:
    C162H262N50O52S2
  • Sequence:
    SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF

    (Modifications: Disulfide bridge between 2 - 7, Phe-37 = C-terminal amide)

  • Solubility:
    Soluble to 0.80 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    83651-90-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Calcitonin gene-related peptide is a potent vasodilator.
    Brain et al.
    Nature, 1985;313:54
  2. Pharmacology of receptors for calcitonin gene-related peptide and amylin.
    Poyner
    TiPS, 1995;16:424
  3. Calcitonin gene-related peptide as a GH secretagogue in human and rat pituitary somatotrophs.
    Nakamura et al.
    Brain Res., 1998;807:203
  4. Isolation and characterization of human calcitonin gene-related peptide.
    Morris et al.
    Nature, 1984;308:746
  5. Calcitonin gene-related peptide potentiates nicotinic acetylcholine receptor-operated slow Ca2+ mobilization at mouse muscle endplates.
    Salim et al.
    Br.J.Pharmacol., 1998;125:277
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CGRP (rat) include:

2 Citations: Showing 1 - 2
Filter your results:

  1. Release of glutamate and CGRP from trigeminal ganglion neurons: Role of calcium channels and 5-HT1 receptor signaling.
    Authors: Xiao Et al.
    Elife 2008;4:12
  2. Orexin 1 receptor activation attenuates neurogenic dural vasodilation in an animal model of trigeminovascular nociception.
    Authors: Holland Et al.
    Mol Pain 2005;315:1380

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