CGS 12066B dimaleate

Name: CGS 12066B dimaleate
Brand: Tocris Bioscience
SKU: 0638
Price: 112 USD
Availability: InStock

Tocris Bioscience | Catalog # 0638

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Citations (7)

Product Documents

5-HT1B agonist

Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

5-HT1B agonist

View all 5-HT1B Receptor Agonists »

Product Description

CGS 12066B dimaleate is a 5-HT_1B full agonist, 10-fold selective over 5-HT_1A and 1000-fold selective over 5-HT_2C receptors. Centrally active following systemic administration.

Product Specifications for CGS 12066B dimaleate

Molecular Weight

566.49

Formula

C₁₇H₁₇F₃N₄.2C₄H₄O₄

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

7-Trifluoromethyl-4-(4-methyl-1-piperazinyl)pyrrolo[1,2-a]-quinoxaline dimaleate

CAS Number

109028-10-6

PubChem ID

9915956

InChI Key

HTEVMLYDEWVIQE-SPIKMXEPSA-N

SMILES

O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O.FC(C1=CC3=C(N2C=CC=C2C(N4CCN(CC4)C)=N3)C=C1)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	2.83	5
	DMSO	22.66	40

Preparing Stock Solutions for CGS 12066B dimaleate

The following data is based on the product molecular weight 566.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.4 mM	4.41 mL	22.07 mL	44.13 mL
2 mM	0.88 mL	4.41 mL	8.83 mL
4 mM	0.44 mL	2.21 mL	4.41 mL
20 mM	0.09 mL	0.44 mL	0.88 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

Schoeffter and Hoyer Interaction of arylpiperazines with 5-HT_1A, 5-HT_1B, 5-HT_1C and 5-HT_1D receptors: do discriminatory 5-HT_1B receptor ligands exist? Naunyn Schmiedebergs Arch.Pharmacol. 1989 PMID: 2770889
Tomkins and O'Neill Effect of 5-HT_1B receptor ligands on self-administration of ethanol in an operant procedure in rats. Pharmacol.Biochem.Behav. 2000 PMID: 10837852
Neale Biochemical and pharmacological characterization of CGS 12066B, a selective serotonin-1B agonist. Eur.J.Pharmacol. 1987 PMID: 3496228

Product Documents for CGS 12066B dimaleate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for CGS 12066B dimaleate

For research use only

Related Research Areas

The Serotonergic System in Alzheimer's Disease

Citations for CGS 12066B dimaleate

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