Catalog Number: 0638
Chemical Name: 7-Trifluoromethyl-4-(4-methyl-1-piperazinyl)pyrrolo[1,2-a]-quinoxaline dimaleate
Biological Activity
5-HT1B full agonist, 10-fold selective over 5-HT1A and 1000-fold selective over 5-HT2C receptors. Centrally active following systemic administration.
Technical Data
  • M.Wt:
    566.49
  • Formula:
    C17H17F3N4.2C4H4O4
  • Solubility:
    Soluble to 5 mM in water and to 40 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    109028-10-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Interaction of arylpiperazines with 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors: do discriminatory 5-HT1B receptor ligands exist?
    Schoeffter and Hoyer
    Naunyn Schmiedebergs Arch.Pharmacol., 1989;339:675
  2. Biochemical and pharmacological characterization of CGS 12066B, a selective serotonin-1B agonist.
    Neale et al.
    Eur.J.Pharmacol., 1987;136:1
  3. Effect of 5-HT1B receptor ligands on self-administration of ethanol in an operant procedure in rats.
    Tomkins and O'Neill
    Pharmacol.Biochem.Behav., 2000;66:129
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CGS 12066B dimaleate include:

2 Citations: Showing 1 - 2
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  1. Lasting neurobehavioral abnormalities in rats after neonatal activation of serotonin 1A and 1B receptors: possible mechanisms for serotonin dysfunction in autistic spectrum disorders.
    Authors: Khatri Et al.
    Psychopharmacology (Berl) 2014;231:1191
  2. Evidence that the deficit in sexual behavior in adult rats neonatally exposed to citalopram is a consequence of 5-HT1 receptor stimulation during development.
    Authors: Maciag Et al.
    Brain Res 2006;1125:171

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