CGS 19755 (CAS 110347-85-8): R&D Systems
Catalog Number: 1241
Chemical Name: cis-4-[Phosphomethyl]-piperidine-2-carboxylic acid
Biological Activity
Potent, competitive NMDA receptor antagonist. Anticonvulsant and neuroprotective. Also available as part of the Mixed NMDA Receptor Tocriset™.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in water
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Behavioral pharmacological profile of CGS 19755, a competitive antagonist at N-methyl-D-aspartate receptors.
    Bennett et al.
    J.Pharmacol.Exp.Ther., 1989;250:454
  2. CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist.
    Lehmann et al.
    J.Pharmacol.Exp.Ther., 1988;246:65
  3. Correlation of CGS 19755 neuroprotection against in vivo excitotoxicity and focal cerebral ischemia.
    Perez-Pinzon et al.
    J.Cereb.Blood Flow Metab., 1995;15:865

The citations listed below are publications that use Tocris products. Selected citations for CGS 19755 include:

4 Citations: Showing 1 - 4
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  1. N-methyl-D-aspartate receptor channel blocker-like discriminative stimulus effects of nitrous oxide gas.
    Authors: Richardson and Shelton
    Cereb Cortex 2015;352:156
  2. Deranged NMDAergic cortico-subthalamic transmission underlies parkinsonian motor deficits.
    Authors: Pan Et al.
    J Pharmacol Exp Ther 2014;124:4629
  3. Potentiation of NMDA receptor-dependent cell responses by extracellular high mobility group box 1 protein.
    Authors: Pedrazzi Et al.
    PLoS One 2012;7:e44518
  4. Neuroprotection associated with alternative splicing of NMDA receptors in rat cortical neurons.
    Authors: Jaekel Et al.
    J Clin Invest 2006;147:622

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