Chemical Name: cis-4-[Phosphomethyl]-piperidine-2-carboxylic acid
Biological ActivityPotent, competitive NMDA receptor antagonist. Anticonvulsant and neuroprotective. Also available as part of the Mixed NMDA Receptor Tocriset™.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Behavioral pharmacological profile of CGS 19755, a competitive antagonist at N-MthD.-aspartate receptors.
Bennett et al.
CGS 19755, a selective and competitive N-MthD.-aspartate-type excitatory amino acid receptor antagonist.
Lehmann et al.
Correlation of CGS 19755 neuroprotection against in vivo excitotoxicity and focal cerebral ischemia.
Perez-Pinzon et al.
J.Cereb.Blood Flow Metab., 1995;15:865
Citations for CGS 19755
The citations listed below are publications that use Tocris products. Selected citations for CGS 19755 include:
4 Citations: Showing 1 - 4
N-MthD.-aspartate receptor channel blocker-like discriminative stimulus effects of nitrous oxide gas.
Authors: Richardson and Shelton
Cereb Cortex 2015;352:156
Deranged NMDAergic cortico-subthalamic transmission underlies parkinsonian motor deficits.
Authors: Pan Et al.
J Pharmacol Exp Ther 2014;124:4629
Potentiation of NMDA receptor-dependent cell responses by extracellular high mobility group box 1 protein.
Authors: Pedrazzi Et al.
PLoS One 2012;7:e44518
Neuroprotection associated with alternative splicing of NMDA receptors in rat cortical neurons.
Authors: Jaekel Et al.
J Clin Invest 2006;147:622
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