Chemical Name: 1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide
Biological ActivityCH 223191 is a potent aryl hydrocarbon receptor (AhR) antagonist (IC50 = 30 nM). Exhibits no AhR agonist-like activity (at concentrations up to 100 μM). Inhibits 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced AhR-dependent transcription in vitro and reduces TCDD-induced toxicity in vivo. Attenuates Th17 differentiation of naive CD4 T cells and promotes expansion of hematopoietic stem cells in vitro.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
CXCR4 activation maintains a stem cell population in tamoxifen-resistant breast cancer cells through AhR signalling.
Dubrovska A, Hartung A, Bouchez LC
Br. J. Cancer, 2012;107(1):43-52.
Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells.
Boitano et al.
Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor.
Kim et al.
Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of TH17 T cells.
Veldhoen et al.
Citations for CH 223191
The citations listed below are publications that use Tocris products. Selected citations for CH 223191 include:
5 Citations: Showing 1 - 5
Increasing kynurenine brain levels reduces ethanol consumption in mice by inhibiting dopamine release in nucleus accumbens.
Authors: Gimenez-Gomez Et al.
Effects of Cigarette Smoke Condensate on Oxidative Stress, Apoptotic Cell Death, and HIV Replication in Human Monocytic Cells.
Authors: Rao Et al.
PLoS One 2016;11:e0155791
A TDO2-AhR Signaling Axis Facilitates Anoikis Resistance and Metastasis in Triple-Negative Breast Cancer.
Authors: D'Amato Et al.
Cancer Res 2015;75:4651
IDO1 suppresses inhibitor development in hemophilia A treated with factor VIII.
Authors: Matino Et al.
Br J Pharmacol 2015;125:3766
Regulation of plasmacytoid dendritic cell development in mice by aryl hydrocarbon receptor.
Authors: Liu Et al.
Immunol Cell Biol 2014;92:200
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for CH 223191
Average Rating: 5 (Based on 1 Review)
Have you used CH 223191?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Compound purity was as described. Efficacy in assays matched previously published results.
Dissolved in DMSO, avoid freeze/thawing.