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CH 223191

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CH 223191 | CAS No. 301326-22-7 | Aryl Hydrocarbon Receptor Antagonists
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Description: Potent aryl hydrocarbon receptor (AhR) antagonist

Chemical Name: 1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide

Purity: ≥98%

Product Details
Citations (5)
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

CH 223191 is a potent aryl hydrocarbon receptor (AhR) antagonist (IC50 = 30 nM). Exhibits no AhR agonist-like activity (at concentrations up to 100 μM). Inhibits 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced AhR-dependent transcription in vitro and reduces TCDD-induced toxicity in vivo. Attenuates Th17 differentiation of naive CD4 T cells and promotes expansion of hematopoietic stem cells in vitro.

Technical Data

M.Wt:
333.39
Formula:
C19H19N5O
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
301326-22-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for CH 223191

The citations listed below are publications that use Tocris products. Selected citations for CH 223191 include:

5 Citations: Showing 1 - 5

  1. Increasing kynurenine brain levels reduces ethanol consumption in mice by inhibiting dopamine release in nucleus accumbens.
    Authors: Gimenez-Gomez Et al.
    Neuropharmacology  2018;135:581
  2. Effects of Cigarette Smoke Condensate on Oxidative Stress, Apoptotic Cell Death, and HIV Replication in Human Monocytic Cells.
    Authors: Rao Et al.
    PLoS One  2016;11:e0155791
  3. A TDO2-AhR Signaling Axis Facilitates Anoikis Resistance and Metastasis in Triple-Negative Breast Cancer.
    Authors: D'Amato Et al.
    Cancer Res  2015;75:4651
  4. IDO1 suppresses inhibitor development in hemophilia A treated with factor VIII.
    Authors: Matino Et al.
    Br J Pharmacol  2015;125:3766
  5. Regulation of plasmacytoid dendritic cell development in mice by aryl hydrocarbon receptor.
    Authors: Liu Et al.
    Immunol Cell Biol  2014;92:200

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protein binding
By Anonymous on 08/20/2018
Application: Species: Human

Compound purity was as described. Efficacy in assays matched previously published results.

Dissolved in DMSO, avoid freeze/thawing.

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