CH 223191

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3858/50
CH 223191 | CAS No. 301326-22-7 | Aryl Hydrocarbon Receptor Antagonists
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Description: Potent aryl hydrocarbon receptor (AhR) antagonist

Chemical Name: 1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide

Purity: ≥98%

Product Details
Citations (4)
Reviews (1)

Biological Activity

Potent aryl hydrocarbon receptor (AhR) antagonist (IC50 = 30 nM). Exhibits no AhR agonist-like activity (at concentrations up to 100 μM). Inhibits 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced AhR-dependent transcription in vitro and reduces TCDD-induced toxicity in vivo. Attenuates Th17 differentiation of naive CD4 T cells and promotes expansion of hematopoietic stem cells in vitro.

Technical Data

M.Wt:
333.39
Formula:
C19H19N5O
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
301326-22-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for CH 223191

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protein binding
By Anonymous on 08/20/2018
Species: Human

Compound purity was as described. Efficacy in assays matched previously published results.

Dissolved in DMSO, avoid freeze/thawing.


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