CH 223191

  ( 4 citations )    
Product Datasheet
Catalog Number:3858
Chemical Name:1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide
Product Details
Citations (4)
Reviews
Biological Activity
Potent aryl hydrocarbon receptor (AhR) antagonist (IC50 = 30 nM). Exhibits no AhR agonist-like activity (at concentrations up to 100 μM). Inhibits 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced AhR-dependent transcription in vitro and reduces TCDD-induced toxicity in vivo. Attenuates Th17 differentiation of naive CD4 T cells and promotes expansion of hematopoietic stem cells in vitro.
Technical Data
  • M.Wt:
    333.39
  • Formula:
    C19H19N5O
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    301326-22-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for CH 223191 include:

4 Citations: Showing 1 - 4
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  1. Effects of Cigarette Smoke Condensate on Oxidative Stress, Apoptotic Cell Death, and HIV Replication in Human Monocytic Cells.
    Authors: Rao Et al.
    PLoS One  2016;11:e0155791
  2. A TDO2-AhR Signaling Axis Facilitates Anoikis Resistance and Metastasis in Triple-Negative Breast Cancer.
    Authors: D'Amato Et al.
    Cancer Res  2015;75:4651
  3. IDO1 suppresses inhibitor development in hemophilia A treated with factor VIII.
    Authors: Matino Et al.
    Br J Pharmacol  2015;125:3766
  4. Regulation of plasmacytoid dendritic cell development in mice by aryl hydrocarbon receptor.
    Authors: Liu Et al.
    Immunol Cell Biol  2014;92:200

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