Home / Aryl Hydrocarbon Receptor Antagonists / CH 223191

CH 223191

3858 5 Citations 1 Review Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3858/10
3858/50
CH 223191 | CAS No. 301326-22-7 | Aryl Hydrocarbon Receptor Antagonists
1 Image
Description: Potent aryl hydrocarbon receptor (AhR) antagonist

Chemical Name: 1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide

Purity: ≥98%

Product Details
Citations (5)
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Potent aryl hydrocarbon receptor (AhR) antagonist (IC50 = 30 nM). Exhibits no AhR agonist-like activity (at concentrations up to 100 μM). Inhibits 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced AhR-dependent transcription in vitro and reduces TCDD-induced toxicity in vivo. Attenuates Th17 differentiation of naive CD4 T cells and promotes expansion of hematopoietic stem cells in vitro.

Technical Data

M.Wt:
333.39
Formula:
C19H19N5O
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
301326-22-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

COA view current batch
or select another batch:
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for CH 223191

The citations listed below are publications that use Tocris products. Selected citations for CH 223191 include:

5 Citations: Showing 1 - 5

  1. Increasing kynurenine brain levels reduces ethanol consumption in mice by inhibiting dopamine release in nucleus accumbens.
    Authors: Gimenez-Gomez Et al.
    Neuropharmacology  2018;135:581
  2. Effects of Cigarette Smoke Condensate on Oxidative Stress, Apoptotic Cell Death, and HIV Replication in Human Monocytic Cells.
    Authors: Rao Et al.
    PLoS One  2016;11:e0155791
  3. A TDO2-AhR Signaling Axis Facilitates Anoikis Resistance and Metastasis in Triple-Negative Breast Cancer.
    Authors: D'Amato Et al.
    Cancer Res  2015;75:4651
  4. IDO1 suppresses inhibitor development in hemophilia A treated with factor VIII.
    Authors: Matino Et al.
    Br J Pharmacol  2015;125:3766
  5. Regulation of plasmacytoid dendritic cell development in mice by aryl hydrocarbon receptor.
    Authors: Liu Et al.
    Immunol Cell Biol  2014;92:200

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for CH 223191

Average Rating: 5 (Based on 1 Review)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used CH 223191?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


protein binding
By Anonymous on 08/20/2018
Application: Species: Human

Compound purity was as described. Efficacy in assays matched previously published results.

Dissolved in DMSO, avoid freeze/thawing.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.