Chicago Sky Blue 6B

Catalog # Availability Size / Price Qty
0846/1G
Chicago Sky Blue 6B | CAS No. 2610-05-1 | Glutamate (EAAT) Transporter Inhibitors
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Description: Dye used as counterstain in histochemistry; also potent inhibitor of L-glutamate uptake into synaptic vesicles; also inhibits MIF

Chemical Name: 6,6'-[(3,3-Dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-amino-5-hydroxy-1,3-napthalenedisulphonic acid] tetrasodium salt

Product Details
Citations (1)
Reviews

Biological Activity

Potent inhibitor of L-glutamate uptake into synaptic vesicles. Allosterically inhibits macrophage migration inhibitory factor (MIF) (IC50 = 0.81 μM); inhibits MIF proinflammatory activity. Also dye used as counterstain in histochemistry.

Technical Data

M.Wt:
992.79
Formula:
C34H24N6Na4O16S4
Solubility:
Soluble to 100 mM in water
Storage:
Store at RT
CAS No:
2610-05-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A novel allosteric inhibitor of macrophage migration inhibitory factor (MIF).
    Bai et al.
    J.Biol.Chem., 2012;287:30653
  2. Uptake of L-glutamate into rat brain synaptic vesicles: effect of inhibitors that bind specifically to the glutamate transport.
    Roseth et al.
    J.Neurochem., 1995;65:96
  3. Inhibitors of amino acid uptake into vesicles.
    Fonnum et al.
    J.Neurochem., 1994;63:Suppl. 1 S49A

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Citation for Chicago Sky Blue 6B

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