hh Chicago Sky Blue 6B (CAS 2610-05-1): R&D Systems
Catalog Number: 0846
Chemical Name: 6,6'-[(3,3-Dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-amino-5-hydroxy-1,3-napthalenedisulphonic acid] tetrasodium salt
Biological Activity
Potent inhibitor of L-glutamate uptake into synaptic vesicles. Allosterically inhibits macrophage migration inhibitory factor (MIF) (IC50 = 0.81 μM); inhibits MIF proinflammatory activity.
Technical Data
  • M.Wt:
    992.79
  • Formula:
    C34H24N6Na4O16S4
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Store at RT
  • CAS No:
    2610-05-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A novel allosteric inhibitor of macrophage migration inhibitory factor (MIF).
    Bai et al.
    J.Biol.Chem., 2012;287:30653
  2. Uptake of L-glutamate into rat brain synaptic vesicles: effect of inhibitors that bind specifically to the glutamate transport.
    Roseth et al.
    J.Neurochem., 1995;65:96
  3. Inhibitors of amino acid uptake into vesicles.
    Fonnum et al.
    J.Neurochem., 1994;63:Suppl. 1 S49A
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Chicago Sky Blue 6B include:

1 Citations: Showing 1 - 1

  1. A novel allosteric inhibitor of macrophage migration inhibitory factor (MIF).
    Authors: Bai Et al.
    J Biol Chem 2012;287:30653

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