Chimaerin 2 Antibody

Name: Chimaerin 2 Antibody
Brand: Novus Biologicals
SKU: NBP1-36945
Price: 399 USD
Availability: InStock

Novus Biologicals | Catalog # NBP1-36945

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (100%), Canine (100%), Mouse (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

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Product Specifications

Immunogen

Peptide with sequence C-QILIENEDVLF corresponding to C-Terminus according to NP_001035025.1, NP_004058.1.

Specificity

This antibody is expected to recognize both reported isoforms (NP_004058.1; NP_001035025.1).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Chimaerin 2 Antibody

Immunohistochemistry-Paraffin: Chimaerin 2 Antibody [NBP1-36945]

Immunohistochemistry-Paraffin: Chimaerin 2 Antibody [NBP1-36945] - 3.8ug/ml staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for Chimaerin 2 Antibody

Application

Recommended Usage

Immunohistochemistry

3 - 6 ug/ml

Immunohistochemistry-Paraffin

3 - 6 ug/ml

Peptide ELISA

Detection limit 1:8000

Western Blot

1:100 - 1:2000

Application Notes

WB: Preliminary experiments in human brain (cerebellum and frontal cortex) lysates gave no specific signal but low background. IHC-P: Human cortex shows staining of neuronal bodies.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Chimaerin 2

Chimaerin 2 is a protein expressed in the brain and pancreas with two isoforms, measuring 468 and 332 amino acids in length with weights of approximately 54 and 38 kDa respectively. Chimaerin 2 functions as a GTP-ase activating protein for p21-rac, and a deficiency in this protein could lead to tumor progression. Current studies are being done on several diseases and disorders related to this protein including b-cell lymphomas, schizophrenia, sleeping sickness, insulin resistance, diabetic retinopathy, malignant glioma, nephropathy, spasticity, astrocytoma, and breast cancer. Chimaerin 2 has also been shown to have interactions with BAG6, NCK1, RAC1, ERBB3, and EIF3C in pathways such as the Rho GTPase cycle, signal transduction, and regulations of RAC1 activity pathways.

Alternate Names

ARHGAP3beta chimerin, BCH, beta-chimaerin, beta-chimerin, chimerin (chimaerin) 2, MGC138360, Rho GTPase-activating protein 3, RhoGAP3, rho-GTPase-activating protein 3

Entrez Gene IDs

1124 (Human)

Gene Symbol

CHN2

UniProt

NP_001035025.1 (Human)

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Product Specific Notices for Chimaerin 2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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