Chk1 Antibody - BSA Free

Novus Biologicals | Catalog # NBP3-30982

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Mouse, Rat, Monkey

Applications

Western Blot, Immunoprecipitation

Label

Unconjugated

Antibody Source

Polyclonal Sheep IgG

Format

BSA Free
View all Chk1 Primary Antibodies »

Product Specifications

Immunogen

Sheep were immunized with a protein corresponding to amino acid sequence 1-474 of human Chk1, having a molecular weight of 54 kDa.

Clonality

Polyclonal

Host

Sheep

Isotype

IgG

Scientific Data Images for Chk1 Antibody - BSA Free

Chk1 Antibody

Western Blot: Chk1 Antibody [NBP3-30982] -

Western Blot: Chk1 Antibody [NBP3-30982] - Western analysis of Chk1 protein in the indicated cell lines. Sheep polyclonal antibody was used at 1:500 dilution.

Applications for Chk1 Antibody - BSA Free

Application
Recommended Usage

Western Blot

: 1-10 ug/ml
Application Notes
.

Formulation, Preparation, and Storage

Purification

Ammonium sulfate precipitation

Formulation

Phosphate buffered saline

Format

BSA Free

Preservative

0.08% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Chk1

Chk1 is involved in cell cycle arrest when DNA damage has occurred, and it plays an important role in DNA damage checkpoint, embryonic development and tumor suppression (1). Chk1 is activated in response to replication blocks and genotoxic stress, via phosphorylation of serines 317 and 345 (2). Activated Chk1 can bind to, phosphorylate (at serine 216) and inactivate cdc25c (3,4). Phosphorylation of cdc25c prevents activation of the CDC2-cyclin B complex and prevents entry into M-phase (3, 4).

Long Name

Checkpoint Kinase 1

Alternate Names

CHEK1

Gene Symbol

CHEK1

Additional Chk1 Products

Product Documents for Chk1 Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for Chk1 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs

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