CHPG Sodium salt
Chemical Name: (RS)-2-Chloro-5-hydroxyphenylglycine sodium salt
Biological ActivitySodium salt of the selective mGlu5 agonist CHPG (Cat. No. 1049).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
(RS)-2-Chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but not mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus.
Doherty et al.
Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel selective mGlu5 antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) in the thalamus.
Salt et al.
Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischaemia.
Bao et al.
Brain Res., 2001;922:173
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