Catalog Number: 3695
Chemical Name: (RS)-2-Chloro-5-hydroxyphenylglycine sodium salt
Biological Activity
Sodium salt of the selective mGlu5 agonist CHPG (Cat. No. 1049).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in water and to 50 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel selective mGlu5 antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) in the thalamus.
    Salt et al.
    Br.J.Pharmacol., 1999;127:1057
  2. Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischaemia.
    Bao et al.
    Brain Res., 2001;922:173
  3. (RS)-2-Chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but not mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus.
    Doherty et al.
    Neuropharmacology, 1997;36:265
Tocris Small Molecules
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