CHPG

  ( 14 citations )    
Product Datasheet
Catalog Number:1049
Chemical Name:(RS)-2-Chloro-5-hydroxyphenylglycine
Product Details
Citations (14)
Supplemental Products
Reviews
Biological Activity
A selective mGlu5 metabotropic glutamate receptor agonist, completely inactive at mGlu1a receptors expressed in CHO cells. Active in vivo.

Sodium Salt also available.

Technical Data
  • M.Wt:
    201.61
  • Formula:
    C8H8NO3Cl
  • Solubility:
    Soluble to 100 mM in 1.1eq. NaOH
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    170846-74-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for CHPG include:

14 Citations: Showing 1 - 10
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  1. The medullary dorsal reticular nucleus as a relay for descending pronociception induced by the mGluR5 in the rat infralimbic cortex.
    Authors: David-Pereira
    Neuroscience  2017;349:341
  2. Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP.
    Authors: Tang Et al.
    J Neurosci  2015;35:3016
  3. Activation of mGluR5 and inhibition of NADPH oxidase improves functional recovery after traumatic brain injury.
    Authors: Loane Et al.
    J Biol Chem  2013;30:403
  4. Anticonvulsive effect of paeoniflorin on experimental febrile seizures in immature rats: possible application for febrile seizures in children.
    Authors: Hino Et al.
    PLoS One  2012;7:e42920
  5. Metabotropic glutamate receptor 5 mediates phosphorylation of vascular endothelial cadherin and nuclear localization of β-catenin in response to homocysteine.
    Authors: Beard Et al.
    Vascul Pharmacol  2012;56:159
  6. The orthosteric agonist 2-chloro-5-hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potency.
    Authors: Kammermeier
    Proc Natl Acad Sci U S A  2012;12:6
  7. mGluR5 positive modulators both potentiate activation and restore inhibition in NMDA receptors by PKC dependent pathway.
    Authors: Chen Et al.
    J Biomed Sci  2011;18:19
  8. Sensory and cortical activation of distinct glial cell subtypes in the somatosensory thalamus of young rats.
    Authors: Parri Et al.
    Eur J Neurosci  2010;32:29
  9. Activation of metabotropic glutamate receptor 5 improves recovery after spinal cord injury in rodents.
    Authors: Byrnes Et al.
    Ann Neurol  2009;66:63
  10. Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity.
    Authors: Byrnes Et al.
    J Neurotrauma  2009;57:550
  11. Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain.
    Authors: Lin Et al.
    J Biomed Sci  2009;16:94
  12. Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro.
    Authors: Neyman and Manahan-Vaughan
    Eur J Neurosci  2008;27:1345
  13. Aberrant early-phase ERK inactivation impedes neuronal function in fragile X syndrome.
    Authors: Kim Et al.
    BMC Pharmacol  2008;105:4429
  14. Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function.
    Authors: Ferré Et al.
    Glia  2002;99:11940
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