A selective mGlu
metabotropic glutamate receptor agonist, completely inactive at mGlu
receptors expressed in CHO cells. Active
Sodium Salt also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel selective mGlu5 antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) in the thalamus.
Salt et al.
Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischaemia.
Bao et al.
Brain Res., 2001;922:173
(RS)-2-Chloro-5-hydroxyphenylglycine (CHPG) activates mGlu 5, but not mGlu 1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus.
Doherty et al.
Potentiation of NMDA and AMPA responses by the specific mGluR5 agonist CHPG in spinal cord motoneurones.
Ugolini et al.
The citations listed below are publications that use Tocris products. Selected citations for CHPG include:
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