Catalog Number: 1049
Chemical Name: (RS)-2-Chloro-5-hydroxyphenylglycine
Biological Activity
A selective mGlu5 metabotropic glutamate receptor agonist, completely inactive at mGlu1a receptors expressed in CHO cells. Active in vivo.

Sodium Salt also available.

Technical Data
  • M.Wt:
    201.61
  • Formula:
    C8H8NO3Cl
  • Solubility:
    Soluble to 100 mM in 1.1eq. NaOH
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    170846-74-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel selective mGlu5 antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) in the thalamus.
    Salt et al.
    Br.J.Pharmacol., 1999;127:1057
  2. Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischaemia.
    Bao et al.
    Brain Res., 2001;922:173
  3. (RS)-2-Chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but not mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus.
    Doherty et al.
    Neuropharmacology, 1997;36:265
  4. Potentiation of NMDA and AMPA responses by the specific mGluR5 agonist CHPG in spinal cord motoneurones.
    Ugolini et al.
    Neuropharmacology, 1999;38:1569
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CHPG include:

12 Citations: Showing 1 - 10
Filter your results:

  1. The medullary dorsal reticular nucleus as a relay for descending pronociception induced by the mGluR5 in the rat infralimbic cortex.
    Authors: David-Pereira
    Neuroscience 2017;349:341
  2. Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP.
    Authors: Tang Et al.
    J Neurosci 2015;35:3016
  3. Activation of mGluR5 and inhibition of NADPH oxidase improves functional recovery after traumatic brain injury.
    Authors: Loane Et al.
    J Biol Chem 2013;30:403
  4. Anticonvulsive effect of paeoniflorin on experimental febrile seizures in immature rats: possible application for febrile seizures in children.
    Authors: Hino Et al.
    PLoS One 2012;7:e42920
  5. The orthosteric agonist 2-chloro-5-hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potency.
    Authors: Kammermeier
    Proc Natl Acad Sci U S A 2012;12:6
  6. Sensory and cortical activation of distinct glial cell subtypes in the somatosensory thalamus of young rats.
    Authors: Parri Et al.
    Eur J Neurosci 2010;32:29
  7. Activation of metabotropic glutamate receptor 5 improves recovery after spinal cord injury in rodents.
    Authors: Byrnes Et al.
    Ann Neurol 2009;66:63
  8. Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity.
    Authors: Byrnes Et al.
    J Neurotrauma 2009;57:550
  9. Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain.
    Authors: Lin Et al.
    J Biomed Sci 2009;16:94
  10. Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro.
    Authors: Neyman and Manahan-Vaughan
    Eur J Neurosci 2008;27:1345
  11. Aberrant early-phase ERK inactivation impedes neuronal function in fragile X syndrome.
    Authors: Kim Et al.
    BMC Pharmacol 2008;105:4429
  12. Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function.
    Authors: Ferré Et al.
    Glia 2002;99:11940
Expand to show all 12 Citations
Tocris Small Molecules
Description Application Cat# Citations Images  

CHPG Sodium salt

3695  
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