Chroman 1

Catalog # Availability Size / Price Qty
7163/50
7163/10
Chroman 1 | Rho-kinase Inhibitors
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Description: Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogenesis

Chemical Name: (3S)-N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-3,4-dihydro-6-methoxy-2H-1-benzopyran-3-carboxamide dihydrochloride

Purity: ≥98%

Product Details
Reviews

Biological Activity

Chroman 1 is a highly potent and selective ROCK2 (Rho-kinase) inhibitor (IC50 values are 1 and 52 pM at ROCK2 and ROCK1, respectively). Chroman 1 exhibits >2000-fold selectivity for ROCK2 over a range of related kinases including MRCK, PKA, and AKT1 (IC50 values are 150, >20000, and >20000 nM, respectively). Chroman 1 promotes survival of pluripotent stem cells (PSCs) in culture when used in combination with Emricasan (Cat. No. 7310), Polyamine Supplement x1000 (lyophilized) (Cat. No. 7739), and trans-ISRIB (Cat. No. 5284), a combination known as CEPT. When used as part of the CEPT cocktail, Chroman 1 also improves survival of differentiated cells following cryopreservation with cardiomyocyte cell survival increasing by 36% and motor neuron survival improving by 63% compared with DMSO controls.

Technical Data

M.Wt:
509.43
Formula:
C24H28N4O4.2HCl
Solubility:
Soluble to 100 mM in DMSO and to 5 mM in water
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitors.
    Chen et al.
    Med.Chem.Commun., 2011;2:73

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