Chemical Name: N,N'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)acetamide]
Biological Activitytrans-ISRIB is an integrated stress response (ISR) inhibitor; reverses the effects of eIF2α phosphorylation (IC50 = 5 nM) and restores cell translation capacity. Acts downstream of PERK, targeting interactions between eIF2α kinases and elF2B. Blocks ATF4 production without altering the IRE1 or ATF6 responses in vitro. Displays memory enhancement in hippocampus-dependent spatial and fear-associated learning in rodents. trans-ISRIB promotes survival of pluripotent stem cells in culture when used in combination with Chroman 1 (Cat. No. 7163), Emricasan (Cat. No. 7310), and Polyamine Supplement x1000 (lyophilized) (Cat. No. 7739), a combination known as CEPT. When used as part of the CEPT cocktail, trans-ISRIB improves survival of differentiated cells following cryopreservation. Brain penetrant.
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Complete Your Research
Pharmacological brake-release of mRNA translation enhances cognitive memory.
Sidrauski et al.
Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound.
Sekine et al.
Cell biology. Blocking stress response for better memory?
Citations for trans-ISRIB
The citations listed below are publications that use Tocris products. Selected citations for trans-ISRIB include:
3 Citations: Showing 1 - 3
Robotic high-throughput biomanufacturing and functional differentiation of human pluripotent stem cells.
Authors: Tristan Et al.
Stem Cell Rep. 2021;16:3076
A versatile polypharmacology platform promotes cytoprotection and viability of human pluripotent and differentiated cells.
Authors: Chen Et al.
GADD34 function in protein trafficking promotes adaptation to hyperosmotic stress in human corneal cells.
Cell Rep. 2017;21(10):2895
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