Catalog Number: 5284
Chemical Name: N,N'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)acetamide]
Biological Activity
Integrated stress response (ISR) inhibitor; reverses the effects of eIF2α phosphorylation (IC50 = 5 nM) and restores cell translation capacity. Acts downstream of PERK, targeting interactions between eIF2α kinases and elF2B. Blocks ATF4 production without altering the IRE1 or ATF6 responses in vitro. Displays memory enhancement in hippocampus-dependent spatial and fear-associated learning in rodents. Brain penetrant.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in DMSO with gentle warming
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pharmacological brake-release of mRNA translation enhances cognitive memory.
    Sidrauski et al.
    Elife, 2013;2:e00498
  2. Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound.
    Sekine et al.
    Science, 2015;348:1027
  3. Cell biology. Blocking stress response for better memory?
    Science, 2015;348:967
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