Integrated stress response (ISR) inhibitor; reverses the effects of eIF2α
= 5 nM) and restores cell translation capacity. Acts downstream of PERK, targeting interactions between eIF2α
kinases and elF2B. Blocks ATF4 production without altering the IRE1 or ATF6 responses in vitro
. Displays memory enhancement in hippocampus-dependent spatial and fear-associated learning in rodents. Brain penetrant.
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All Tocris products are intended for laboratory research use only.
Pharmacological brake-release of mRNA translation enhances cognitive memory.
Sidrauski et al.
Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound.
Sekine et al.
Cell biology. Blocking stress response for better memory?