trans-ISRIB

  ( 1 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:5284
Chemical Name:N,N'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)acetamide]
Product Details
Citations (1)
Reviews
Biological Activity
Integrated stress response (ISR) inhibitor; reverses the effects of eIF2α phosphorylation (IC50 = 5 nM) and restores cell translation capacity. Acts downstream of PERK, targeting interactions between eIF2α kinases and elF2B. Blocks ATF4 production without altering the IRE1 or ATF6 responses in vitro. Displays memory enhancement in hippocampus-dependent spatial and fear-associated learning in rodents. Brain penetrant.
Technical Data
  • M.Wt:
    451.34
  • Formula:
    C22H24Cl2N2O4
  • Solubility:
    Soluble to 10 mM in DMSO with gentle warming
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    1597403-47-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for trans-ISRIB include:

1 Citations: Showing 1 - 1

  1. GADD34 function in protein trafficking promotes adaptation to hyperosmotic stress in human corneal cells.
    Authors: Krokowski
    Cell Rep  2017;21(10):2895

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs
Average Rating: 5 (Based on 1 review)

Have you used trans-ISRIB?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Read what people are saying who have used trans-ISRIB.

We have 1 review tested in 1 species: Rat.

Filter by Ratings
Excellent
(1)
All Ratings
Filter by Applications
All Applications
Filter by Species
Rat
(1)
All Species

Images Ratings Applications Species Reviewed By Date Details
  Excellent
  Rat Anonymous 11/01/2017
Show

Summary

Species Rat

Please scroll the above reviews for more
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee