Catalog Number: 1412
Chemical Name: trans-N-[6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide
Biological Activity
Blocker of the slow delayed rectifier K+ current (IKs) (IC50 = 1-10 μM). Also blocks the CFTR chloride current (ICFTR) (IC50 = 19 μM).

Enantiomer also available.

Technical Data
  • M.Wt:
    324.39
  • Formula:
    C15H20N2O4S
  • Solubility:
    Soluble to 20 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    163163-23-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Chromanol 293B, a blocker of the slow delayed rectifier K+ current (IKS), inhibits the CFTR Cl- current.
    Bachmann et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 2001;363:590
  2. Time-dependent block of the slowly activating delayed rectifier K+ current by chromanol 293B in guinea-pig ventricular cells.
    Fujisawa et al.
    Br.J.Pharmacol., 2000;129:1007
  3. Chromanol 293B inhibits slowly activating delayed rectifier and transient outward currents in canine left ventricular myocytes.
    Sun et al.
    J.Cardiovasc.Electrophysiol., 2001;12:472
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Chromanol 293B include:

2 Citations: Showing 1 - 2
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  1. Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents.
    Authors: Yu Et al.
    J Cell Mol Med 2014;9:e96691
  2. The contribution of Kv7 channels to pregnant mouse and human myometrial contractility.
    Authors: McCallum Et al.
    Mol Pain 2011;15:577
Tocris Small Molecules
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(-)-[3R,4S]-Chromanol 293B

1475 2  
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