Chemical Name: trans-N-[6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide
Biological ActivityChromanol 293B is a blocker of the slow delayed rectifier K+ current (IKs) (IC50 = 1-10 μM). Also blocks the CFTR chloride current (ICFTR) (IC50 = 19 μM).
Enantiomer also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Chromanol 293B, a blocker of the slow delayed rectifier K+ current (IKS), inhibits the CFTR Cl- current.
Bachmann et al.
Naunyn Schmiedebergs Arch.Pharmacol., 2001;363:590
Time-dependent block of the slowly activating delayed rectifier K+ current by chromanol 293B in guinea-pig ventricular cells.
Fujisawa et al.
Chromanol 293B inhibits slowly activating delayed rectifier and transient outward currents in canine left ventricular myocytes.
Sun et al.
Citations for Chromanol 293B
The citations listed below are publications that use Tocris products. Selected citations for Chromanol 293B include:
5 Citations: Showing 1 - 5
Involvement of butyrate in electrogenic K+ secretion in rat rectal colon.
Authors: Inagaki Et al.
Pflugers Arch 2019;471:313
Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents.
Authors: Yu Et al.
J Cell Mol Med 2014;9:e96691
Renal defects in KCNE1 knockout mice are mimicked by chromanol 293B in vivo: identification of a KCNE1-regulated K+ conductance in the proximal tubule.
Authors: Neal Et al.
J Physiol 2011;589:3595
The contribution of Kv7 channels to pregnant mouse and human myometrial contractility.
Authors: McCallum Et al.
Mol Pain 2011;15:577
KCNE3 truncation mutants reveal a bipartite modulation of KCNQ1 K+ channels.
Authors: Gage and Kobertz
J Gen Physiol 2004;124:759
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