Chromanol 293B

Tocris Bioscience | Catalog # 1412

IKs blocker. Also blocks ICFTR
Tocris Bioscience

Key Product Details

Description

IKs blocker. Also blocks ICFTR
View all Voltage-gated Potassium Channel Blockers »

Product Description

Chromanol 293B is a blocker of the slow delayed rectifier K+ current (IKs) (IC50 = 1-10 μM). Also blocks the CFTR chloride current (ICFTR) (IC50 = 19 μM).

Enantiomer also available.

Product Specifications for Chromanol 293B

Molecular Weight

324.39

Formula

C15H20N2O4S

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

trans-N-[6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide

CAS Number

163163-23-3

PubChem ID

121846

InChI Key

HVSJHHXUORMCGK-UONOGXRCSA-N

SMILES

O[C@H]1[C@H](N(C)S(=O)(CC)=O)C2=C(C=CC(C#N)=C2)OC(C)1C.O[C@@H]3[C@@H](N(C)S(=O)(CC)=O)C4=C(C=CC(C#N)=C4)OC(C)3C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.44 100
Ethanol 6.49 20

Preparing Stock Solutions for Chromanol 293B

The following data is based on the product molecular weight 324.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.08 mL 15.41 mL 30.83 mL
5 mM 0.62 mL 3.08 mL 6.17 mL
10 mM 0.31 mL 1.54 mL 3.08 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 47 publications citing the usage of this product.

Product Documents for Chromanol 293B

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Chromanol 293B

For research use only

Customer Reviews for Chromanol 293B (1)

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  • Chromanol 293B was used to assess how it regulates the gating kinetics of Kv2.1
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 11/29/2018
    Chromanol 293B was used to assess how it regulates the gating kinetics of Kv2.1. The blocking action exhibited by the product was measured on epithelial Kv2.1 channels.
    Chromanol 293B 1412

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