Chromanol 293B

  ( 4 citations )    
Product Datasheet
Catalog Number:1412
Chemical Name:trans-N-[6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide
Product Details
Citations (4)
Supplemental Products
Reviews
Biological Activity
Blocker of the slow delayed rectifier K+ current (IKs) (IC50 = 1-10 μM). Also blocks the CFTR chloride current (ICFTR) (IC50 = 19 μM).

Enantiomer also available.

Technical Data
  • M.Wt:
    324.39
  • Formula:
    C15H20N2O4S
  • Solubility:
    Soluble to 20 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    163163-23-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Chromanol 293B include:

4 Citations: Showing 1 - 4
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  1. Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents.
    Authors: Yu Et al.
    J Cell Mol Med  2014;9:e96691
  2. Renal defects in KCNE1 knockout mice are mimicked by chromanol 293B in vivo: identification of a KCNE1-regulated K+ conductance in the proximal tubule.
    Authors: Neal Et al.
    J Physiol  2011;589:3595
  3. The contribution of Kv7 channels to pregnant mouse and human myometrial contractility.
    Authors: McCallum Et al.
    Mol Pain  2011;15:577
  4. KCNE3 truncation mutants reveal a bipartite modulation of KCNQ1 K+ channels.
    Authors: Gage and Kobertz
    J Gen Physiol  2004;124:759

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