Chemical Name: N-[6-(4-Chlorophenoxy)hexyl]-N'-cyano-N''-4-pyridinylguanidine
Biological ActivityCHS 828 is a NAMPT inhibitor. Decreases cellular level of NAD+. Selectively increases intracellular ROS levels in cancer cells but not normal cells. Active in vivo and cytotoxic.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
CHS 828, a novel pyridyl cyanoguanidine with potent antitumor activity in vitro and in vivo.
Hjarnaa et al.
Cancer Res., 1999;59:5751
Nicotinamide phosphoribosyltransferase inhibitor as a novel payload for antibody-drug conjugates.
Karpov et al.
ACS Med.Chem.Lett., 2018;9:838
Anticancer agent CHS-828 inhibits cellular synthesis of NAD.
Olesen et al.
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