CHS 828

Key Product Details

Product Description

CHS 828 is a NAMPT inhibitor. Decreases cellular level of NAD⁺. Selectively increases intracellular ROS levels in cancer cells but not normal cells. Active in vivo and cytotoxic.

Product Specifications for CHS 828

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CHS 828

The following data is based on the product molecular weight 371.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.69 mL	13.45 mL	26.89 mL
5 mM	0.54 mL	2.69 mL	5.38 mL
10 mM	0.27 mL	1.34 mL	2.69 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Karpov Nicotinamide phosphoribosyltransferase inhibitor as a novel payload for antibody-drug conjugates. ACS Med.Chem.Lett. 2018 PMID: 30128077
• Olesen Anticancer agent CHS-828 inhibits cellular synthesis of NAD. Biochem.Biophys.Res.Commun. 2008 PMID: 18201551
• Hjarnaa CHS 828, a novel pyridyl cyanoguanidine with potent antitumor activity in vitro and in vivo. Cancer Res. 1999 PMID: 10582695

Product Documents for CHS 828