Chemical Name: 6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone
Biological ActivityCiclopirox is a pan-histone demethylase inhibitor. Exhibits no significant effect on histone deacetylases. Inhibits MYC-signaling and proliferation of neuroblastoma cells. Promotes Cdc25A-degradation in cancer cells. Antifungal.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Ciclopirox inhibits cancer cell proliferation by suppression of Cdc25A.
Shen et al.
Genes Cancer, 2017;8:505
Targeting histone demethylases in MYC-driven neuroblastomas with ciclopirox.
Yang et al.
Cancer Res., 2017;77:4626
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