CID 2858522

Discontinued Product

4246 has been discontinued.
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CID 2858522 | CAS No. 758679-97-9 | NFkB/IkB Inhibitors
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Description: Selectively inhibits PKC-induced NF-κB activation

Chemical Name: 1-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-[2-[(3-hydroxypropyl)amino]-5,6-dimethyl-1H-benzimidazol-1-yl]ethanone

Purity: ≥98%

Product Details
Citations (1)

Biological Activity

CID 2858522 is a selectively inhibits protein kinase C (PKC)-induced activation of the NF-κB pathway (IC50 < 0.1 μM for PMA-stimulated IL-8 production). Inhibits antigen receptor-stimulated NF-κB activation in chronic lymphocytic leukemia (CLL) B cells. Does not inhibit other NF-κB pathways, including that activated by tumor necrosis factor (TNF).

Technical Data

Soluble to 20 mM in DMSO and to 20 mM in ethanol
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Inhibition of protein kinase C-driven NF-κB activation: synthesis, SAR, and pharmacological profiling of pathway specific benzimidazole probe molecules.
    Peddibhotla et al.
    J.Med.Chem., 2010;53:4793
  2. Chemical biology strategy reveals pathway-selective inhibitor of NF-κB activation induced by protein kinase C and antigen receptors.
    Shi et al.
    ACS Chem.Bio., 2010;5:287

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Citation for CID 2858522

The citations listed below are publications that use Tocris products. Selected citations for CID 2858522 include:

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