Chemical Name: 1-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-[2-[(3-hydroxypropyl)amino]-5,6-dimethyl-1H-benzimidazol-1-yl]ethanone
Biological ActivitySelectively inhibits protein kinase C (PKC)-induced activation of the NF-κB pathway (IC50 < 0.1 μM for PMA-stimulated IL-8 production). Inhibits antigen receptor-stimulated NF-κB activation in chronic lymphocytic leukemia (CLL) B cells. Does not inhibit other NF-κB pathways, including that activated by tumor necrosis factor (TNF).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibition of protein kinase C-driven NF-κB activation: synthesis, SAR, and pharmacological profiling of pathway specific benzimidazole probe molecules.
Peddibhotla et al.
Chemical biology strategy reveals pathway-selective inhibitor of NF-κB activation induced by protein kinase C and antigen receptors.
Shi et al.
ACS Chem.Bio., 2010;5:287
Citation for CID 2858522
The citations listed below are publications that use Tocris products. Selected citations for CID 2858522 include:
1 Citation: Showing 1 - 1
Cell line with endogenous EGFRvIII expression is a suitable model for research and drug development purposes.
Authors: Stec Et al.
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