CID 2858522

Key Product Details

Product Description

CID 2858522 is a selectively inhibits protein kinase C (PKC)-induced activation of the NF-κB pathway (IC₅₀ < 0.1 μM for PMA-stimulated IL-8 production). Inhibits antigen receptor-stimulated NF-κB activation in chronic lymphocytic leukemia (CLL) B cells. Does not inhibit other NF-κB pathways, including that activated by tumor necrosis factor (TNF).

Product Specifications for CID 2858522

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CID 2858522

The following data is based on the product molecular weight 465.63.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	10.74 mL	53.69 mL	107.38 mL
1 mM	2.15 mL	10.74 mL	21.48 mL
2 mM	1.07 mL	5.37 mL	10.74 mL
10 mM	0.21 mL	1.07 mL	2.15 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Shi Chemical biology strategy reveals pathway-selective inhibitor of NF-κB activation induced by protein kinase C and antigen receptors. ACS Chem.Bio.
• Peddibhotla Inhibition of protein kinase C-driven NF-κB activation: synthesis, SAR, and pharmacological profiling of pathway specific benzimidazole probe molecules. J.Med.Chem. 2010 PMID: 20481485

Product Documents for CID 2858522