Cilengitide (CAS 188968-51-6): R&D Systems
Catalog Number: 5870
Alternate Names: EMD121974
Biological Activity
Potent and selective inhibitor of integrins αvβ3 and αvβ5 (IC50 values are 4.1 and 70 nM, respectively). Exhibits ~10-fold selectivity over gpIIb/IIIa. Increases endothelial monolayer permeability. Also exhibits antiangiogenic activity.
Technical Data
  • M.Wt:
    588.66
  • Formula:
    C27H40N8O7
  • Sequence:
    RGDFV

    (Modifications: Phe-4 = D-Phe, Val-5 = Me-Val, Cyclizedl)

  • Solubility:
    Soluble to 10 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    188968-51-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. CYR61 and αvβ5 integrin cooperate to promote invasion and metastasis of tumors growing in preirradiated stroma.
    Monnier et al.
    Cancer Res., 2008;68:7323
  2. The integrin antagonist cilengitide activates αvβ3, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cells.
    Alghisi et al.
    PLoS One, 2009;4:e4449

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