Cilengitide

Tocris Bioscience | Catalog # 5870

Potent and selective inhibitor of integrins αvβ3 and αvβ5
Tocris Bioscience

Key Product Details

Description

Potent and selective inhibitor of integrins αvβ3 and αvβ5

Alternative Names

EMD121974
View all Integrin Receptor Inhibitors »

Product Description

Cilengitide is a potent and selective inhibitor of integrins αvβ3 and αvβ5 (IC50 values are 4.1 and 70 nM, respectively). Exhibits ~10-fold selectivity over gpIIb/IIIa. Increases endothelial monolayer permeability. Also exhibits antiangiogenic activity.

Product Specifications for Cilengitide

Molecular Weight

588.66

Formula

C27H40N8O7

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

188968-51-6

PubChem ID

176873

InChI Key

AMLYAMJWYAIXIA-VWNVYAMZSA-N

SMILES

CC(C)[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C(=O)N1C)CC2=CC=CC=C2)CC(=O)O)CCCN=C(N)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 10mg/ml in water

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 21 publications citing the usage of this product.

Product Documents for Cilengitide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Cilengitide

For research use only

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