Cilostamide

  ( 5 citations )    
Product Datasheet
Catalog Number:0915
Alternate Names:OCP 3689
Chemical Name:N-Cyclohexyl-N-methyl-4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyramide
Product Details
Citations (5)
Reviews
Biological Activity
Selective inhibitor of type III phosphodiesterase (PDE3). Displays moderate selectivity for PDE3A isozyme vs. PDE3B (IC50 values are 0.027 and 0.050 μM for PDE3A and PDE3B respectively). Inhibits ADP-induced platelet aggregation (IC50 = 16.8 μM); antithrombotic. Also available as part of the Phosphodiesterase Inhibitor Tocriset™.
Technical Data
  • M.Wt:
    342.44
  • Formula:
    C20H26N2O3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Storage:
    Store at RT
  • CAS No:
    68550-75-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Cilostamide include:

5 Citations: Showing 1 - 5
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  1. Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol.
    Authors: Merino Et al.
    PLoS One  2015;10:e0132884
  2. The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium.
    Authors: Ørstavik Et al.
    J Biol Chem  2015;10:e0115547
  3. Alteration of vascular reactivity in heart failure: role of phosphodiesterases 3 and 4.
    Authors: Hubert Et al.
    Br J Pharmacol  2014;171:5361
  4. Increased intracellular magnesium attenuates β-adrenergic stimulation of the cardiac Ca(V)1.2 channel.
    Authors: Brunet Et al.
    J Gen Physiol  2013;141:85
  5. β-Adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells.
    Authors: Zhai Et al.
    PLoS One  2012;7:e47826

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