Cilostamide

Catalog # Availability Size / Price Qty
0915/10
0915/50
Cilostamide | CAS No. 68550-75-4 | Phosphodiesterase Inhibitors
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Description: PDE3 inhibitor
Alternative Names: OCP 3689

Chemical Name: N-Cyclohexyl-N-methyl-4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyramide

Product Details
Citations (5)
Reviews

Biological Activity

150Selective inhibitor of type III phosphodiesterase (PDE3). Displays moderate selectivity for PDE3A isozyme vs. PDE3B (IC50 values are 0.027 and 0.050 μM for PDE3A and PDE3B respectively). Inhibits ADP-induced platelet aggregation (IC50 = 16.8 μM); antithrombotic.

Technical Data

M.Wt:
342.44
Formula:
C20H26N2O3
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at RT
CAS No:
68550-75-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
    Tollefson and Taylor
    CNS Drug Reviews, 2000;6:303
  2. Selective inhibitor of platelet cyclic adenosine monophosphate phosphodiesterase, cilostamide, inhibits platelet aggregation.
    Hidaki et al.
    J.Pharmacol.Exp.Ther., 1979;211:26
  3. Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phosphodiesterase isozyme activity.
    Sudo et al.
    Biochem.Pharmacol., 2000;59:347
  4. Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents.
    Christensen and Torphy
    Annu.Rep.Med.Chem., 1994;29:185

Product Datasheets

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Citations for Cilostamide

The citations listed below are publications that use Tocris products. Selected citations for Cilostamide include:

5 Citations: Showing 1 - 5

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