Selective inhibitor of type III phosphodiesterase (PDE3). Displays moderate selectivity for PDE3A isozyme vs. PDE3B (IC50
values are 0.027 and 0.050 μ
M for PDE3A and PDE3B respectively). Inhibits ADP-induced platelet aggregation (IC50
= 16.8 μ
M); antithrombotic. Also available as part of the Phosphodiesterase Inhibitor Tocriset™
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
Menge et al.
J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
Selective inhibitor of platelet cyclic adenosine monophosphate phosphodiesterase, cilostamide, inhibits platelet aggregation.
Hidaki et al.
Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phosphodiesterase isozyme activity.
Sudo et al.
The citations listed below are publications that use Tocris products. Selected citations for Cilostamide include:
Showing Results 1 - 4 of 4