CIMBA hydrochloride

Key Product Details

Product Description

CIMBA hydrochloride is a potent G protein-coupled estrogen receptor (GPER) antagonist (IC₅₀ = 75 nM). In vivo, it prevents the formation of estrogen-induced cholesterol gallstones by inhibiting the GPER pathway in female ovariectomized mice.

Licensing Information

Sold under licence from Saint Louis University.

Product Specifications for CIMBA hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CIMBA hydrochloride

The following data is based on the product molecular weight 373.97.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.67 mL	13.37 mL	26.74 mL
5 mM	0.53 mL	2.67 mL	5.35 mL
10 mM	0.27 mL	1.34 mL	2.67 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• DeLeon A novel GPER antagonist protects against the formation of estrogen-induced cholesterol gallstones in female mice. J.Lipid Res. 2020 PMID: 32127396

Product Documents for CIMBA hydrochloride