cis-6-Hydroxynorketamine hydrochloride

Tocris Bioscience | Catalog # 5982

Enhances AMPA currents: antidepressant
Tocris Bioscience

Key Product Details

Description

Enhances AMPA currents: antidepressant
View all Additional NMDA Receptor Compounds »

Product Description

cis

-6-Hydroxynorketamine hydrochloride is a metabolite of ketamine. Increases AMPA receptor-mediated excitatory post-synaptic potentials in the CA1 region of hippocampal slices. Exhibits antidepressive effects in vivo.

2S,6S-enantiomer and 2R,6R-enantiomer also available.

Product Specifications for cis-6-Hydroxynorketamine hydrochloride

Molecular Weight

276.16

Formula

C12H14ClNO2.HCl

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

cis-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride

CAS Number

2319601-04-0

PubChem ID

121513910

InChI Key

ZQJVHBJDLMIKJK-MHDYBILJSA-N

SMILES

ClC1=C([C@@]2(N)C([C@H](O)CCC2)=O)C=CC=C1.ClC3=C([C@]4(N)C([C@@H](O)CCC4)=O)C=CC=C3.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 27.62 100
DMSO 27.62 100

Preparing Stock Solutions for cis-6-Hydroxynorketamine hydrochloride

The following data is based on the product molecular weight 276.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.62 mL 18.11 mL 36.21 mL
5 mM 0.72 mL 3.62 mL 7.24 mL
10 mM 0.36 mL 1.81 mL 3.62 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for cis-6-Hydroxynorketamine hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for cis-6-Hydroxynorketamine hydrochloride

For research use only

Citations for cis-6-Hydroxynorketamine hydrochloride

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