Chemical Name: cis-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride
Biological ActivityMetabolite of ketamine. Increases AMPA receptor-mediated excitatory post-synaptic potentials in the CA1 region of hippocampal slices. Exhibits antidepressive effects in vivo.
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NMDAR inhibition-independent antidepressant actions of ketamine metabolites.
Zanos et al.
Comparative pharmacology in the rat of ketamine and its two principal metabolites, norketamine and (Z)-6-hydroxynorketamine.
Leung and Baillie
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