Chemical Name: cis-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride
Biological ActivityMetabolite of ketamine. Increases AMPA receptor-mediated excitatory post-synaptic potentials in the CA1 region of hippocampal slices. Exhibits antidepressive effects in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
NMDAR inhibition-independent antidepressant actions of ketamine metabolites.
Zanos et al.
Comparative pharmacology in the rat of ketamine and its two principal metabolites, norketamine and (Z)-6-hydroxynorketamine.
Leung and Baillie
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