Catalog Number: 5982
Chemical Name: cis-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride
Biological Activity
Metabolite of ketamine (Cat.No. 3131). Increases AMPA receptor-mediated excitatory post-synaptic potentials in the CA1 region of hippocampal slices. Exhibits antidepressive effects in vivo. 2S,2S- and 2R,6R-enantiomers available. 2R,6R-enantiomer lacks ketamine-related side effects.
Technical Data
  • M.Wt:
    276.16
  • Formula:
    C12H14ClNO2.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Comparative pharmacology in the rat of ketamine and its two principal metabolites, norketamine and (Z)-6-hydroxynorketamine.
    Leung and Baillie
    J.Med.Chem., 1986;29:2396
  2. NMDAR inhibition-independent antidepressant actions of ketamine metabolites.
    Zanos et al.
    Nature, 2016;533:481

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