Chemical Name: 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride
Biological ActivityNon-competitive NMDA receptor antagonist (EC50 values are 13.6 and 17.6 μM for GluN1/GluN2A (formally NR1 and NR2A, respectively) and GluN1/GluN2B (formally NR1 and NR2B, respectively) subunit combinations respectively). Dissociative anesthetic.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions. .
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The dissociative anaesthetics, KA and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate.
Anis et al.
Effects of KA, a noncompetitive NMDA antagonist, on the acquisition of the lever-press response in rats.
Pallares et al.
Modulation of NMDA receptor function by KA and magnesium: part I.
Liu et al.
Citation for Ketamine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Ketamine hydrochloride include:
1 Citation: Showing 1 - 1
Glutamate antagonists limit tumor growth.
Authors: Rzeski Et al.
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