Non-competitive NMDA receptor antagonist (EC50
values are 13.6 and 17.6 μ
M for NR1/NR2A and NR1/NR2B subunit combinations respectively). Dissociative anesthetic. S-enantiomer
(Cat. No. 4379) also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate.
Anis et al.
Effects of ketamine, a noncompetitive NMDA antagonist, on the acquisition of the lever-press response in rats.
Pallares et al.
Modulation of NMDA receptor function by ketamine and magnesium: part I.
Liu et al.
The citations listed below are publications that use Tocris products. Selected citations for Ketamine hydrochloride include:
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