Ketamine hydrochloride

Tocris Bioscience | Catalog # 3131

Non-competitive NMDA receptor antagonist
Tocris Bioscience

Key Product Details

Description

Non-competitive NMDA receptor antagonist
View all NMDA Receptor Antagonists »

Product Description

Ketamine hydrochloride is a non-competitive NMDA receptor antagonist (EC50 values are 13.6 and 17.6 μM for GluN1/GluN2A (formally NR1 and NR2A, respectively) and GluN1/GluN2B (formally NR1 and NR2B, respectively) subunit combinations respectively). Dissociative anesthetic.

S-enantiomer and Active metabolite also available.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions. .

Product Specifications for Ketamine hydrochloride

Molecular Weight

274.19

Formula

C13H16ClNO.HCl

Storage

Store at RT

Purity

≥99% (HPLC)

Chemical Name

2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride

CAS Number

1867-66-9

PubChem ID

15851

InChI Key

VCMGMSHEPQENPE-UHFFFAOYSA-N

SMILES

O=C1C(C2=CC=CC=C2Cl)(NC)CCCC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 27.42 100

Preparing Stock Solutions for Ketamine hydrochloride

The following data is based on the product molecular weight 274.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.65 mL 18.24 mL 36.47 mL
5 mM 0.73 mL 3.65 mL 7.29 mL
10 mM 0.36 mL 1.82 mL 3.65 mL
50 mM 0.07 mL 0.36 mL 0.73 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 41 publications citing the usage of this product.

Product Documents for Ketamine hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Ketamine hydrochloride

For research use only

Citations for Ketamine hydrochloride

Customer Reviews for Ketamine hydrochloride (1)

5 out of 5
1 Customer Rating
5 Stars
100%
4 Stars
0%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used Ketamine hydrochloride?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card

Customer Images

Showing  1 - 1 of 1 review Showing All
Filter By:
Clear Filters X
  • Anaesthetic and antidepressant drug - works well
    Name: Luiz Alexandre Magno
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 11/11/2022
    Ketamine should be mixed with xylazine for anaesthesia.
    Ketamine hydrochloride from Tocris has been used in my lab as a potent intraperitoneal anaesthetic for general surgery and also as a candidate drug for treating depression. It has worked well so far. The image shows data from mice anesthetized with an intraperitoneal injection of ketamine solution at 80 mg/kg. The drug was diluted in sterile saline.
    Ketamine hydrochloride 3131

There are no reviews that match your criteria.

Showing  1 - 1 of 1 review Showing All