Ketamine hydrochloride

Catalog # Availability Size / Price Qty
3131/50
Ketamine hydrochloride | CAS No. 1867-66-9 | NMDA Receptor Antagonists
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Description: Non-competitive NMDA receptor antagonist

Chemical Name: 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride

Purity: ≥99%

Product Details
Citations (1)
Reviews

Biological Activity

Non-competitive NMDA receptor antagonist (EC50 values are 13.6 and 17.6 μM for GluN1/GluN2A (formally NR1 and NR2A, respectively) and GluN1/GluN2B (formally NR1 and NR2B, respectively) subunit combinations respectively). Dissociative anesthetic.

S-enantiomer and Active metabolite also available.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions. .

Technical Data

M.Wt:
274.19
Formula:
C13H16ClNO.HCl
Solubility:
Soluble to 100 mM in water
Purity:
≥99%
Storage:
Store at RT
CAS No:
1867-66-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. The dissociative anaesthetics, KA and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate.
    Anis et al.
    Br.J.Pharmacol., 1983;79:565
  2. Effects of KA, a noncompetitive NMDA antagonist, on the acquisition of the lever-press response in rats.
    Pallares et al.
    Physiol.Behav., 1995;57:389
  3. Modulation of NMDA receptor function by KA and magnesium: part I.
    Liu et al.
    Anesth.Pharmacol., 2001;92:1173

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Citation for Ketamine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Ketamine hydrochloride include:

1 Citation: Showing 1 - 1

  1. Glutamate antagonists limit tumor growth.
    Authors: Rzeski Et al.
    Oncotarget  2001;98:6372

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