Catalog Number: 3131
Chemical Name: 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride
Biological Activity
Non-competitive NMDA receptor antagonist (EC50 values are 13.6 and 17.6 μM for NR1/NR2A and NR1/NR2B subunit combinations respectively). Dissociative anesthetic.

S-enantiomer and Active metabolite also available.

Technical Data
  • M.Wt:
    274.19
  • Formula:
    C13H16ClNO.HCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    1867-66-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate.
    Anis et al.
    Br.J.Pharmacol., 1983;79:565
  2. Effects of ketamine, a noncompetitive NMDA antagonist, on the acquisition of the lever-press response in rats.
    Pallares et al.
    Physiol.Behav., 1995;57:389
  3. Modulation of NMDA receptor function by ketamine and magnesium: part I.
    Liu et al.
    Anesth.Pharmacol., 2001;92:1173
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ketamine hydrochloride include:

1 Citations: Showing 1 - 1

  1. Glutamate antagonists limit tumor growth.
    Authors: Rzeski Et al.
    Oncotarget 2001;98:6372
Tocris Small Molecules
Description Application Cat# Citations Images  

(S)-(+)-Ketamine hydrochloride

4379  
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