cis MZ 1
Chemical Name: (2S,4S)-1-((S)-2-(tert-butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Biological Activitycis MZ 1 is a negative Control for MZ1 (Cat.No. 6154). Exhibits no significant VHL binding affinity.
External Portal InformationChemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of MZ 1 is reviewed on the chemical probes website.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Selective small molecule induced degradation of the BET bromodomain protein BRD4.
Zengerle et al.
ACS Chem.Biol., 2015;10:1770
Citation for cis MZ 1
The citations listed below are publications that use Tocris products. Selected citations for cis MZ 1 include:
1 Citation: Showing 1 - 1
Activity of BET-proteolysis targeting chimeric (PROTAC) compounds in triple negative breast cancer.
Authors: Noblejas-Lopez Et al.
J Exp Clin Cancer Res 2019;38:383
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