Chemical Name: (1S,3S)-1-[3-[[4-(2-Fluorophenyl)piperazin-1-yl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
Biological ActivityIrreversible nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist; inhibits Ca2+ release (IC50 = 800 nM) and [32P]NAADP binding (IC50 = 15 μM). Stereoisomer of trans-Ned 19. Fluorescently labels NAADP receptors in intact cells (excitation 351 and 365 nm using an ultraviolet Argon laser).
Isomer of trans-Ned 19.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of a chemical probe for NAADP by virtual screening.
Naylor et al.
Citations for cis-Ned 19
The citations listed below are publications that use Tocris products. Selected citations for cis-Ned 19 include:
2 Citations: Showing 1 - 2
Both RyRs and TPCs are required for NAADP-induced intracellular Ca2+ release.
Authors: Gerasimenko Et al.
Sci Rep 2015;58:237
VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling.
Authors: Favia Et al.
Proc Natl Acad Sci U S A 2014;111:E4706
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