cis-Ned 19

Catalog # Availability Size / Price Qty
3953/10
Cat.No. 3953 - cis-Ned 19 | C30H31FN4O3 | CAS No. 1137264-00-6
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Description: NAADP antagonist; inhibits Ca2+ release

Chemical Name: (1S,3S)-1-[3-[[4-(2-Fluorophenyl)piperazin-1-yl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid

Product Details
Citations (2)
Reviews

Biological Activity

Irreversible nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist; inhibits Ca2+ release (IC50 = 800 nM) and [32P]NAADP binding (IC50 = 15 μM). Stereoisomer of trans-Ned 19. Fluorescently labels NAADP receptors in intact cells (excitation 351 and 365 nm using an ultraviolet Argon laser).

Isomer of trans-Ned 19.

Technical Data

Formula:
C30H31FN4O3
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
CAS No:
1137264-00-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Other Product-Specific Information:

Background References

  1. Identification of a chemical probe for NAADP by virtual screening.
    Naylor et al.
    Nat.Chem.Biol., 2009;5:220

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Citations for cis-Ned 19

The citations listed below are publications that use Tocris products. Selected citations for cis-Ned 19 include:

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