cis-Ned 19

  ( 1 citations )    
Product Datasheet
Catalog Number:3953
Chemical Name:(1S,3S)-1-[3-[[4-(2-Fluorophenyl)piperazin-1-yl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
Product Details
Citations (1)
Reviews
Biological Activity
Irreversible nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist; inhibits Ca2+ release (IC50 = 800 nM) and [32P]NAADP binding (IC50 = 15 μM). Stereoisomer of trans-Ned 19. Fluorescently labels NAADP receptors in intact cells (excitation 351 and 365 nm using an ultraviolet Argon laser).

Isomer of trans-Ned 19.

Technical Data
  • M.Wt:
    514.59
  • Formula:
    C30H31FN4O3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >97
  • Storage:
    Store at -20°C
  • CAS No:
    1137264-00-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
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Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for cis-Ned 19 include:

1 Citations: Showing 1 - 1

  1. Both RyRs and TPCs are required for NAADP-induced intracellular Ca2+ release.
    Authors: Gerasimenko Et al.
    Sci Rep  2015;58:237

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