cis-Ned 19

Catalog # Availability Size / Price Qty
3953/10
Calcium Signaling Agents Small Molecule
1 Image
Description: NAADP antagonist; inhibits Ca2+ release

Chemical Name: (1S,3S)-1-[3-[[4-(2-Fluorophenyl)piperazin-1-yl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid

Purity: ≥97%

Product Details
Citations (2)
Reviews

Biological Activity

Irreversible nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist; inhibits Ca2+ release (IC50 = 800 nM) and [32P]NAADP binding (IC50 = 15 μM). Stereoisomer of trans-Ned 19. Fluorescently labels NAADP receptors in intact cells (excitation 351 and 365 nm using an ultraviolet Argon laser).

Isomer of trans-Ned 19.

Technical Data

M.Wt:
514.59
Formula:
C30H31FN4O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
1137264-00-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. Identification of a chemical probe for NAADP by virtual screening.
    Naylor et al.
    Nat.Chem.Biol., 2009;5:220

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Citations for cis-Ned 19

The citations listed below are publications that use Tocris products. Selected citations for cis-Ned 19 include:

2 Citations: Showing 1 - 2

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