trans-Ned 19

Catalog # Availability Size / Price Qty
3954/10
trans-Ned 19 | CAS No. 1354235-96-3 | Calcium Signaling Agents
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Description: NAADP antagonist; inhibits Ca2+ release

Chemical Name: (1R,3S)-1-[3-[[4-(2-Fluorophenyl)piperazin-1-yl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid

Purity: ≥98%

Product Details
Citations (6)
Reviews

Biological Activity

trans-Ned 19 is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Inhibits NAADP-mediated Ca2+ release (IC50 = 6 nM); also inhibits [32P]NAADP binding (IC50 = 0.4 nM). Fluorescently labels NAADP receptors in intact cells. Stereosiomer of cis-Ned 19 (Cat. No. 3953).

Optical Data for trans-Ned 19

λabs 368 nm
λem 425 nm
Closest Laser line 355 nm
Cell Permeable Yes
Application Confocal Microscopy

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Technical Data

M.Wt:
514.59
Formula:
C30H31FN4O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1354235-96-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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