Chemical Name: (1R,3S)-1-[3-[[4-(2-Fluorophenyl)piperazin-1-yl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
Biological ActivityNicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Inhibits NAADP-mediated Ca2+ release (IC50 = 6 nM); also inhibits [32P]NAADP binding (IC50 = 0.4 nM). Fluorescently labels NAADP receptors in intact cells. Stereosiomer of cis-Ned 19 (Cat. No. 3953).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of a chemical probe for NAADP by virtual screening.
Naylor et al.
Analogues of the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist Ned-19 indicate two binding sites on the NAADP receptor.
Rosen et al.
NAADP receptors mediate calcium signaling stimulated by endothelin-1 and NE in renal afferent arterioles.
Thai et al.
Am.J.Physiol.Renal Physiol., 2009;297:F510
Citations for trans-Ned 19
The citations listed below are publications that use Tocris products. Selected citations for trans-Ned 19 include:
2 Citations: Showing 1 - 2
Cross-talk between CD38 and TTP is essential for resolution of inflammation during microbial sepsis.
Authors: Joe Et al.
Cell Rep. 2020;30:1063
NAADP-Dependent Ca(2+) Signaling Controls Melanoma Progression, Metastatic Dissemination and Neoangiogenesis.
Authors: Favia Et al.
Toxicol Lett 2016;6:18925
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for trans-Ned 19
There are currently no reviews for this product. Be the first to review trans-Ned 19 and earn rewards!
Have you used trans-Ned 19?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image