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trans-Ned 19

Catalog #: 3954
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3954/10
trans-Ned 19 | CAS No. 1354235-96-3 | Calcium Signaling Agents
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Description: Fluorescently labels NAADP receptors in intact cells; inhibits Ca2+ release

Chemical Name: (1R,3S)-1-[3-[[4-(2-Fluorophenyl)piperazin-1-yl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid

Purity: ≥98%

Product Details
Citations (2)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

trans-Ned 19 is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Inhibits NAADP-mediated Ca2+ release (IC50 = 6 nM); also inhibits [32P]NAADP binding (IC50 = 0.4 nM). Fluorescently labels NAADP receptors in intact cells. Stereosiomer of cis-Ned 19 (Cat. No. 3953).

Technical Data

M.Wt:
514.59
Formula:
C30H31FN4O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1354235-96-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for trans-Ned 19

The citations listed below are publications that use Tocris products. Selected citations for trans-Ned 19 include:

2 Citations: Showing 1 - 2

  1. Cross-talk between CD38 and TTP is essential for resolution of inflammation during microbial sepsis.
    Authors: Joe Et al.
    Cell Rep.  2020;30:1063
  2. NAADP-Dependent Ca(2+) Signaling Controls Melanoma Progression, Metastatic Dissemination and Neoangiogenesis.
    Authors: Favia Et al.
    Toxicol Lett  2016;6:18925

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