Nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Inhibits NAADP-mediated Ca2+
= 6 nM); also inhibits [32
P]NAADP binding (IC50
= 0.4 nM). Fluorescently labels NAADP receptors in intact cells. Stereosiomer of cis-Ned 19
(Cat. No. 3953).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Identification of a chemical probe for NAADP by virtual screening.
Naylor et al.
Analogues of the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist Ned-19 indicate two binding sites on the NAADP receptor.
Rosen et al.
NAADP receptors mediate calcium signaling stimulated by endothelin-1 and norepinephrine in renal afferent arterioles.
Thai et al.
Am.J.Physiol.Renal Physiol., 2009;297:F510
The citations listed below are publications that use Tocris products. Selected citations for trans-Ned 19 include:
Showing Results 1 - 1 of 1