Chemical Name: (1R,3S)-1-[3-[[4-(2-Fluorophenyl)piperazin-1-yl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
Biological Activitytrans-Ned 19 is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Inhibits NAADP-mediated Ca2+ release (IC50 = 6 nM); also inhibits [32P]NAADP binding (IC50 = 0.4 nM). Fluorescently labels NAADP receptors in intact cells. Stereosiomer of cis-Ned 19 (Cat. No. 3953).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of a chemical probe for NAADP by virtual screening.
Naylor et al.
Analogues of the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist Ned-19 indicate two binding sites on the NAADP receptor.
Rosen et al.
NAADP receptors mediate calcium signaling stimulated by endothelin-1 and NE in renal afferent arterioles.
Thai et al.
Am.J.Physiol.Renal Physiol., 2009;297:F510
Citations for trans-Ned 19
The citations listed below are publications that use Tocris products. Selected citations for trans-Ned 19 include:
2 Citations: Showing 1 - 2
Cross-talk between CD38 and TTP is essential for resolution of inflammation during microbial sepsis.
Authors: Joe Et al.
Cell Rep. 2020;30:1063
NAADP-Dependent Ca(2+) Signaling Controls Melanoma Progression, Metastatic Dissemination and Neoangiogenesis.
Authors: Favia Et al.
Toxicol Lett 2016;6:18925
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