Cladribine

  ( 1 citations )    
Product Datasheet
Catalog Number:5292
Alternate Names:2-Chloro-2'-deoxyadenosine
Chemical Name:(2R,3S,5R)-5-(6-Amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxalan-3-ol
Product Details
Citations (1)
Reviews
Biological Activity
Adenosine deaminase (ADA)-resistant analog of deoxyadenosine. Exhibits anti-leukemic activity; Inhibits cell growth of lymphoid and myeloid neoplasm (IC50 = 20 - 87 nM). Pro-apoptotic; induces DNA double-strand breaks. Also inhibits ribonuclease reductase (IC50 = 0.11 - 0.28 μM). Displays activity in vitro and in vivo. Orally bioavailable.
Technical Data
  • M.Wt:
    285.69
  • Formula:
    C10H12ClN5O3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    4291-63-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Cladribine include:

1 Citations: Showing 1 - 1

  1. Galactomannan and Zymosan Block the Epinephrine-Induced Particle Transport in Tracheal Epithelium.
    Authors: Weiterer Et al.
    J Biomed Sci  2015;10:e0143163

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used Cladribine?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee