Claudin-1 Antibody - BSA Free

Name: Claudin-1 Antibody - BSA Free
Brand: Novus Biologicals
SKU: NBP2-38578
Price: 329 USD
Availability: InStock

Novus Biologicals | Catalog # NBP2-38578

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Product Documents

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Cited:

Mouse

Predicted:

Mouse (96%), Rat (96%). Backed by our 100% Guarantee.

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

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Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: KTTSYPTPRPYPKPAPSSGKDYV

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Claudin-1 Antibody - BSA Free

Immunohistochemistry-Paraffin: Claudin-1 Antibody [NBP2-38578]

Immunohistochemistry-Paraffin: Claudin-1 Antibody [NBP2-38578] - Staining in human skin and skeletal muscle tissues using NBP2-38578 antibody. Corresponding CLDN1 RNA-seq data are presented for the same tissues.

Western Blot: Claudin-1 Antibody [NBP2-38578]

Western Blot: Claudin-1 Antibody [NBP2-38578] - Analysis in human cell lines A-431 and U-251MG. Corresponding RNA-seq data are presented for the same cell lines. Loading control: Anti-HSP90B1.

Immunohistochemistry-Paraffin: Claudin-1 Antibody [NBP2-38578]

Immunohistochemistry-Paraffin: Claudin-1 Antibody [NBP2-38578] - Staining of human fallopian tube shows moderate to strong membranous positivity in glandular cells.

Immunohistochemistry-Paraffin: Claudin-1 Antibody [NBP2-38578]

Immunohistochemistry-Paraffin: Claudin-1 Antibody [NBP2-38578] - Staining of human liver shows moderate membranous positivity in hepatocytes.

Immunohistochemistry-Paraffin: Claudin-1 Antibody [NBP2-38578]

Immunohistochemistry-Paraffin: Claudin-1 Antibody [NBP2-38578] - Staining of human skeletal muscle shows no positivity in myocytes as expected.

Immunohistochemistry-Paraffin: Claudin-1 Antibody [NBP2-38578]

Immunohistochemistry-Paraffin: Claudin-1 Antibody [NBP2-38578] - Staining of human skin shows strong membranous positivity in squamous epithelial cells.

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Applications for Claudin-1 Antibody - BSA Free

Application

Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200

Western Blot

0.04 - 0.4 ug/ml

Application Notes

IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Claudin-1

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.

Alternate Names

Claudin1, CLD1, CLDN1, SEMP1

Gene Symbol

CLDN1

UniProt

O95832

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Product Specific Notices for Claudin-1 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.