Catalog Number: 1453
Chemical Name: (2R)-2-[2-[(1R)-1-(4-Chlorophenylethoxy]ethyl]-1-methyl-2-pyrrolidine fumarate
Biological Activity
H1-receptor antagonist. Clinically-used antihistamine.
Technical Data
  • M.Wt:
    459.97
  • Formula:
    C21H26ClNO.C4H4O4
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    14976-57-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Histamine1-histamine2 antagonism: effect of combined clemastine and cimetidine pretreatment on allergen and histamine-induced reactions of the guinea pig lung in vivo and in vitro.
    Dorsch et al.
    Agents Actions, 1982;12:113
  2. Effect of histamine and histamine antagonists on natural and antibody-dependent cellular cytotoxicity of human lymphocytes in vitro.
    Nair and Schwartz
    Cell.Immunol., 1983;81:45
  3. Modulation of histamine-induced bronchoconstriction with inhaled, oral, and intravenous clemastine in normal and asthmatic subjects.
    Hartmann et al.
    Thorax, 1981;36:737
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Clemastine fumarate include:

1 Citations: Showing 1 - 1

  1. Clemastine potentiates the human P2X7 receptor by sensitizing it to lower ATP concentrations.
    Authors: Nörenberg Et al.
    J Biol Chem 2011;286:11067

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