Clemizole hydrochloride

Key Product Details

Product Description

TRPC5 channel blocker (IC₅₀ values are 1.1, 6.4, 9.1, 11.3 and 26.5 μM for TRPC5, TRPC4, TRPC3, TRPC6 and TRPC7 respectively). Exhibits minimal effect on TRPM3, TRPM8 and TRPV1-4 channels. Also histamine H₁ receptor antagonist and anticonvulsant in zebrafish Dravet syndrome model.

Product Specifications for Clemizole hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Clemizole hydrochloride

The following data is based on the product molecular weight 362.30.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.52 mL	27.60 mL	55.20 mL
2.5 mM	1.10 mL	5.52 mL	11.04 mL
5 mM	0.55 mL	2.76 mL	5.52 mL
25 mM	0.11 mL	0.55 mL	1.10 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Richter Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol.Pharm. 2014 PMID: 25140002
• Baraban Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nat.Commun. 2013 PMID: 24002024
• Aguilar Pharmacological investigation into the effects of histamine and histamine analogues on guinea-pig and rat colon in vitro. Br.J.Pharmacol. 1986 PMID: 3742147

Product Documents for Clemizole hydrochloride