Clobenpropit dihydrobromide

Key Product Details

Product Description

An extremely potent histamine H₃ antagonist/inverse agonist (pA₂=9.93). Also displays partial agonist activity at H₄ receptors; induces eosinophil shape change with an EC₅₀ of 3 nM.

Licensing Information

Sold with the permission of SCI, Amsterdam

Product Specifications for Clobenpropit dihydrobromide

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Clobenpropit dihydrobromide

The following data is based on the product molecular weight 470.65.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.12 mL	10.62 mL	21.25 mL
5 mM	0.42 mL	2.12 mL	4.25 mL
10 mM	0.21 mL	1.06 mL	2.12 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 21 publications citing the usage of this product.

• Van der Goot Isothiourea analogues of histamine as potent agonists or antagonists of the histamine H₃ receptor. Eur.J.Med.Chem.
• Liu Cloning and pharmacological characterization of a fourth histamine receptor (H₄) expressed in bone marrow. Mol. Pharmacol. 2001 PMID: 11179434
• Yokoyama Clobenpropit (VUF-9153), a new histamine H₃ receptor antagonist, inhibits electrically induced convulsions in mice. Eur.J.Pharmacol. 1994 PMID: 7957622
• Buckland Histamine induces cytoskeletal changes in human eosinophils via the H₄ receptor. Br.J.Pharmacol. 2003 PMID: 14530216

Product Documents for Clobenpropit dihydrobromide