An extremely potent histamine H3
antagonist/inverse agonist (pA2
=9.93). Also displays partial agonist activity at H4
receptors; induces eosinophil shape change with an EC50
of 3 nM. Also available as part of the Histamine H3 Receptor Tocriset™
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold with the permission of SCI, Amsterdam
Histamine induces cytoskeletal changes in human eosinophils via the H4 receptor.
Buckland et al.
Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
Menge et al.
J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
Cloning and pharmacological characterization of a fourth histamine receptor (H4) expressed in bone marrow.
Liu et al.
Mol. Pharmacol., 2001;59:420
Clobenpropit (VUF-9153), a new histamine H3 receptor antagonist, inhibits electrically induced convulsions in mice.
Yokoyama et al.
The citations listed below are publications that use Tocris products. Selected citations for Clobenpropit dihydrobromide include:
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