Catalog Number: 0752
Alternate Names: VUF 9153
Chemical Name: N-(4-Chlorobenzyl)-S-[3-(4(5)-imidazolyl)propyl]isothiourea dihydrobromide
Biological Activity
An extremely potent histamine H3 antagonist/inverse agonist (pA2=9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM. Also available as part of the Histamine H3 Receptor Tocriset™.
Technical Data
  • M.Wt:
    470.65
  • Formula:
    C14H17ClN4S.2HBr
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    145231-35-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of SCI, Amsterdam
Background References
  1. Histamine induces cytoskeletal changes in human eosinophils via the H4 receptor.
    Buckland et al.
    Br.J.Pharmacol., 2003;140:1117
  2. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  3. Cloning and pharmacological characterization of a fourth histamine receptor (H4) expressed in bone marrow.
    Liu et al.
    Mol. Pharmacol., 2001;59:420
  4. Clobenpropit (VUF-9153), a new histamine H3 receptor antagonist, inhibits electrically induced convulsions in mice.
    Yokoyama et al.
    Eur.J.Pharmacol., 1994;260:23
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Clobenpropit dihydrobromide include:

3 Citations: Showing 1 - 3
Filter your results:

  1. Histidine Decarboxylase Deficiency Prevents Autoimmune Diabetes in NOD Mice.
    Authors: Alkan Et al.
    J Immunol 2015;2015:965056
  2. Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression.
    Authors: Femenia Et al.
    Int J Neuropsychopharmacol 2015;18
  3. Molecular pharmacology of human NMDA receptors.
    Authors: Hedegaard Et al.
    Neurochem Int 2012;61:601

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