Catalog Number: 0752
Alternate Names: VUF 9153
Chemical Name: N-(4-Chlorobenzyl)-S-[3-(4(5)-imidazolyl)propyl]isothiourea dihydrobromide
Biological Activity
An extremely potent histamine H3 antagonist/inverse agonist (pA2=9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM. Also available as part of the Histamine H3 Receptor Tocriset™.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of SCI, Amsterdam
Background References
  1. Histamine induces cytoskeletal changes in human eosinophils via the H4 receptor.
    Buckland et al.
    Br.J.Pharmacol., 2003;140:1117
  2. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  3. Cloning and pharmacological characterization of a fourth histamine receptor (H4) expressed in bone marrow.
    Liu et al.
    Mol. Pharmacol., 2001;59:420
  4. Clobenpropit (VUF-9153), a new histamine H3 receptor antagonist, inhibits electrically induced convulsions in mice.
    Yokoyama et al.
    Eur.J.Pharmacol., 1994;260:23

The citations listed below are publications that use Tocris products. Selected citations for Clobenpropit dihydrobromide include:

Showing Results 1 - 3 of 3

  1. Histidine Decarboxylase Deficiency Prevents Autoimmune Diabetes in NOD Mice.
    Authors: Alkan Et al.
    J Immunol
  2. Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression.
    Authors: Femenia Et al.
    Int J Neuropsychopharmacol
  3. Molecular pharmacology of human NMDA receptors.
    Authors: Hedegaard Et al.
    Neurochem Int
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details


Contact Information

Molarity Calculator
Calculate the mass, volume or concentration required for a solution

The molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) x Volume (L) x Molecular Weight (g/mol)
An example of a molarity calculation using the molarity calculator:
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?

R&D Systems Guarantee

or select another batch:


Customer Information