Clobenpropit dihydrobromide

Catalog # Availability Size / Price Qty
0752/10
0752/50

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Clobenpropit dihydrobromide | CAS No. 145231-35-2 | Histamine H3 Receptor Antagonists
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Description: Highly potent H3 antagonist and H4 partial agonist
Alternative Names: VUF 9153

Chemical Name: N-(4-Chlorobenzyl)-S-[3-(4(5)-imidazolyl)propyl]isothiourea dihydrobromide

Purity: ≥99%

Product Details
Citations (4)
Supplemental Products
Reviews

Biological Activity

An extremely potent histamine H3 antagonist/inverse agonist (pA2=9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM.

Technical Data

M.Wt:
470.65
Formula:
C14H17ClN4S.2HBr
Solubility:
Soluble to 100 mM in water
Purity:
≥99%
Storage:
Store at RT
CAS No:
145231-35-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of SCI, Amsterdam

Background References

  1. Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
    Tollefson and Taylor
    CNS Drug Reviews, 2000;6:303
  2. Histamine induces cytoskeletal changes in human eosinophils via the H4 receptor.
    Buckland et al.
    Br.J.Pharmacol., 2003;140:1117
  3. Cloning and pharmacological characterization of a fourth histamine receptor (H4) expressed in bone marrow.
    Liu et al.
    Mol. Pharmacol., 2001;59:420
  4. Isothiourea analogues of histamine as potent agonists or antagonists of the histamine H3 receptor.
    Van der Goot et al.
    Eur.J.Med.Chem., 1992;27:511
  5. Clobenpropit (VUF-9153), a new histamine H3 receptor antagonist, inhibits electrically induced convulsions in mice.
    Yokoyama et al.
    Eur.J.Pharmacol., 1994;260:23

Product Datasheets

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Citations for Clobenpropit dihydrobromide

The citations listed below are publications that use Tocris products. Selected citations for Clobenpropit dihydrobromide include:

4 Citations: Showing 1 - 4

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