CMPD-1

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2186/10
2186/50
CMPD-1 | CAS No. 41179-33-3 | p38 Inhibitors
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Description: Selective inhibitor of p38α-mediated MK2a phosphorylation; also tubulin polymerization inhibitor

Chemical Name: 2'-Fluoro-N-(4-hydroxyphenyl)-[1,1'-biphenyl]-4-butanamide

Purity: ≥99%

Product Details
Citations (3)
Reviews (1)

Biological Activity

Non-ATP-competitive, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-2a) phosphorylation (apparent Ki = 330 nM). Does not inhibit p38α-mediated phosphorylation of MBP and ATF-2. Also tubulin polymerization inhibitor. Cytotoxic in glioblastoma cells at concentrations that do not affect the MK2 pathway.

Technical Data

M.Wt:
349.4
Formula:
C22H20FNO2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
41179-33-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2.
    Gurgis et al.
    Cell Death Discovery, 2015;1:15028
  2. Discovery and characterisation of a substrate selective p38α inhibitor.
    Davidson et al.
    Biochemistry, 2004;43:11658

Product Datasheets

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Citations for CMPD-1

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42 perturbagens used the zebrafish DASPEI screen
By Anonymous on 12/17/2019
Application: Species: Other

Zebrafish larvae were placed into 48-well plates and used the DASPEI screen by 42 perturbagens drugs, including this compound

PMID: 30532693

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