Non-ATP-competitive, selective inhibitor of p38α
-mediated MK2a (mitogen-activated protein kinase-2a) phosphorylation (apparent Ki
= 330 nM). Does not inhibit p38α
-mediated phosphorylation of MBP and ATF-2. Also tubulin polymerization inhibitor. Cytotoxic in glioblastoma cells at concentrations that do not affect the MK2 pathway.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Discovery and characterisation of a substrate selective p38α inhibitor.
Davidson et al.
Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2.
Gurgis et al.
Cell Death Discovery, 2015;1:15028
The citations listed below are publications that use Tocris products. Selected citations for CMPD-1 include:
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