Catalog Number: 2186
Chemical Name: 2'-Fluoro-N-(4-hydroxyphenyl)-[1,1'-biphenyl]-4-butanamide
Biological Activity
Non-ATP-competitive, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-2a) phosphorylation (apparent Ki = 330 nM). Does not inhibit p38α-mediated phosphorylation of MBP and ATF-2. Also tubulin polymerization inhibitor. Cytotoxic in glioblastoma cells at concentrations that do not affect the MK2 pathway.
Technical Data
  • M.Wt:
    349.4
  • Formula:
    C22H20FNO2
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    41179-33-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Discovery and characterisation of a substrate selective p38α inhibitor.
    Davidson et al.
    Biochemistry, 2004;43:11658
  2. Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2.
    Gurgis et al.
    Cell Death Discovery, 2015;1:15028
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CMPD-1 include:

1 Citations: Showing 1 - 1

  1. EGF receptor activates MET through MAPK to enhance non-small cell lung carcinoma invasion and brain metastasis.
    Authors: Breindel Et al.
    Cancer Res 2013;73:5053

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