Chemical Name: 2'-Fluoro-N-(4-hydroxyphenyl)-[1,1'-biphenyl]-4-butanamide
Biological ActivityNon-ATP-competitive, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-2a) phosphorylation (apparent Ki = 330 nM). Does not inhibit p38α-mediated phosphorylation of MBP and ATF-2. Also tubulin polymerization inhibitor. Cytotoxic in glioblastoma cells at concentrations that do not affect the MK2 pathway.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2.
Gurgis et al.
Cell Death Discovery, 2015;1:15028
Discovery and characterisation of a substrate selective p38α inhibitor.
Davidson et al.
Citations for CMPD-1
The citations listed below are publications that use Tocris products. Selected citations for CMPD-1 include:
3 Citations: Showing 1 - 3
The Inner Ear Heat Shock Transcriptional Signature Identifies Compounds That Protect Against Aminoglycoside Ototoxicity.
Authors: Ryals Et al.
Front Cell Neurosci 2018;12:445
p38 and OGT sequestration into viral inclusion bodies in cells infected with human respiratory syncytial virus suppresses MK2 activities and stress granule assembly.
Authors: Fricke Et al.
J Virol 2013;87:1333
EGF receptor activates MET through MAPK to enhance non-small cell lung carcinoma invasion and brain metastasis.
Authors: Breindel Et al.
Cancer Res 2013;73:5053
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Zebrafish larvae were placed into 48-well plates and used the DASPEI screen by 42 perturbagens drugs, including this compound