Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (94%), Rat (94%). Backed by our 100% Guarantee.

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all CNPase Primary Antibodies »

Product Specifications

Immunogen

Reacts with residues 68-84 of the 46-48 (doublet) kDa human, CNPase protein (74% sequence identity and 94% sequence similarity to mouse and rat).

Reactivity Notes

Human. 94% sequence identity with mouse and rat.

Marker

Oligodendrocyte Marker

Specificity

CNPase - Oligodendrocyte Marker

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

45 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for CNPase Antibody - BSA Free

Western Blot: CNPase AntibodyBSA Free [NB110-79874]

Western Blot: CNPase AntibodyBSA Free [NB110-79874]

Western Blot: CNPase Antibody [NB110-79874] - Analysis of CNPase in 10ug of normal brain tissue lysate using CNPase antibody NB110-79874 at a dilution of 1:500

Applications for CNPase Antibody - BSA Free

Application
Recommended Usage

Western Blot

1:100-1:2000
Application Notes
This antibody is useful in Western Blot, ELISA and Immunohistochemistry

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CNPase

CNPase (2',3'-Cyclic Nucleotide 3'-Phosphodiesterase) exists in two forms: 46kDa (CNP1) and 48kDa (CNP2). It is expressed at high levels by oligodendrocytes in the central nervous system and by Schwann cells in the peripheral nervous system and is virtual absent in other cell types. CNPase activity is decreased in demyelinating diseases such as multiple sclerosis. CNPase gene is localized to chromosome 17q21, very near the BRCA 1 familial breast cancer gene.

Alternate Names

2', 3' cyclic nucleotide 3' phosphohydrolase, 2'-3'-cyclic nucleotide 3' phosphodiesterase, 2'-3'-cyclic-nucleotide 3'-phosphodiesterase, CNP1, CNPase, EC 3.1.4.37

Entrez Gene IDs

1267 (Human); 12799 (Mouse); 25275 (Rat)

Gene Symbol

CNP

Additional CNPase Products

Product Documents for CNPase Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for CNPase Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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