Novel, potent and selective antagonist of NR2B-containing NMDA receptors (IC50
values are 0.043, > 100 and > 100 μ
M for NR1A/2B, NR1A/2A and NR1A/2C subunit combinations respectively). Displays neuroprotective effects in vivo
and in vitro
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All Tocris products are intended for laboratory research use only.
4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist.
Zhou et al.
Pharmacological characterization of Ro 63-1908 (1-[2-(4-hydroxy-phenoxy)-ethyl]-4-(4-methyl-benzyl)-piperidin-4-ol), a novel subtype-selective N-methyl-D-aspartate antagonist.
Gill et al.
Evaluation of the NR2B-selective NMDA receptor antagonist Ro 63-1908 on rodent behaviour: evidence for an involvement of NR2B NMDA receptors in response inhibition.
Higgins et al.
The citations listed below are publications that use Tocris products. Selected citations for Co 101244 hydrochloride include:
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