Co 101244 hydrochloride

Catalog # Availability Size / Price Qty
Co 101244 hydrochloride | CAS No. 193356-17-1 | NMDA Receptor Antagonists
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Description: GluN2B-selective NMDA antagonist
Alternative Names: PD 174494, Ro 63-1908

Chemical Name: 1-[2-(4-Hydroxyphenoxy)ethyl]-4-[(4-methylphenyl)methyl]-4-piperidinol hydrochloride

Purity: ≥99%

Product Details
Citations (3)
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Biological Activity

Co 101244 hydrochloride is a novel, potent and selective antagonist of GluN2B (formally NR2B)-containing NMDA receptors (IC50 values are 0.043, > 100 and > 100 μM for GluN1A/2B (NR1A/2B), GluN1A/2A (NR1A/2A) and GluN1A/2C (NR1A/2C) subunit combinations respectively). Displays neuroprotective effects in vivo and in vitro.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data

Soluble to 100 mM in water and to 50 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Co 101244 hydrochloride

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