Biological ActivityColivelin is a neuroprotective peptide and activator of STAT3. Protects neurons against the neurotoxic effects of amyloid β-peptide (1-43) at a concentration of 100 fM in vitro. Suppresses neuronal death by activating STAT3 in vitro; upregulates cholinergic transmission and ameliorates memory impairment in Alzheimer's disease (AD) models. Also prevents alcohol-induced apoptosis in a fetal mouse model. Brain penetrant.
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A novel peptide, colivelin, prevents alcohol-induced apoptosis in fetal brain of C57BL/6 mice: signaling pathway investigations.
Sari et al.
Nasal colivelin treatment ameliorates memory impairment related to Alzheimer's disease.
Yamada et al.
Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro a
Chiba et al.
Citation for Colivelin
The citations listed below are publications that use Tocris products. Selected citations for Colivelin include:
1 Citation: Showing 1 - 1
Long-term heart transplant survival by targeting the ionotropic purinergic receptor P2X7.
Authors: Vergani Et al.
J Cell Biol 2013;127:463
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