Catalog Number: 3945
Biological Activity
Neuroprotective peptide and activator of STAT3. Protects neurons against the neurotoxic effects of amyloid β-peptide (1-43) at a concentration of 100 fM in vitro. Suppresses neuronal death by activating STAT3 in vitro; upregulates cholinergic transmission and ameliorates memory impairment in Alzheimer's disease (AD) models. Also prevents alcohol-induced apoptosis in a fetal mouse model. Brain penetrant.
Technical Data
  • M.Wt:
    2645.13
  • Formula:
    C119H206N32O35
  • Sequence:
    SALLRSIPAPAGASRLLLLTGEIDLP
  • Solubility:
    Soluble to 1 mg/ml in 20% ethanol / water
  • Storage:
    Store at -20°C
  • CAS No:
    867021-83-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vit
    Chiba et al.
    J.Neurosci., 2005;25:10252
  2. Nasal colivelin treatment ameliorates memory impairment related to Alzheimer's disease.
    Yamada et al.
    Neuropsychopharmacology, 2008;33:2020
  3. A novel peptide, colivelin, prevents alcohol-induced apoptosis in fetal brain of C57BL/6 mice: signaling pathway investigations.
    Sari et al.
    Neuroscience, 2009;164:1653
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Colivelin include:

1 Citations: Showing 1 - 1

  1. Long-term heart transplant survival by targeting the ionotropic purinergic receptor P2X7.
    Authors: Vergani Et al.
    J Cell Biol 2013;127:463

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