FR 122047 hydrochloride

Key Product Details

Product Description

FR 122047 hydrochloride is a selective cyclooxygenase-1 (COX-1) inhibitor (IC₅₀ values are 0.028 and 65 μM for COX-1 and COX-2 respectively). Antiplatelet, analgesic and anti-inflammatory following oral administration in vivo.

Product Specifications for FR 122047 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for FR 122047 hydrochloride

The following data is based on the product molecular weight 459.99.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.74 mL	108.70 mL	217.40 mL
0.5 mM	4.35 mL	21.74 mL	43.48 mL
1 mM	2.17 mL	10.87 mL	21.74 mL
5 mM	0.43 mL	2.17 mL	4.35 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Tanaka Antiplatelet agents based on cyclooxygenase inhibition without ulcerogenesis. Evaluation and synthesis of 4,5-bis(4-methoxyphenyl)-2-substituted-thiazoles. J.Med.Chem. 1994 PMID: 8164261
• Ochi The analgesic effect profile of FR122047, a selective cyclo-oxygenase-1 inhibitor, in chemical nociceptive models. Eur.J.Pharmacol. 2000 PMID: 10720634
• Ochi and Goto Differential effect of FR122047, a selective cyclo-oxygenase-1 inhibitor, in rat chronic models of arthritis. Br.J.Pharmacol. 2002 PMID: 11834626
• Dohi The anti-platelet actions of FR122047, a novel cyclooxygenase inhibitor. Eur.J.Pharmacol. 1993 PMID: 8276067

Product Documents for FR 122047 hydrochloride