Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Janelia Fluor 549

Antibody Source

Monoclonal Mouse IgG2B Clone # 354113
View all Complement Component C3a Primary Antibodies »

Product Specifications

Immunogen

E. coli-derived recombinant human Complement Component C3a
Ser672-Arg748
Accession # P01024

Specificity

Detects human Complement Component C3a in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human (rh) Complement Component C5a or rhComplement Component C3d is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications for Complement Component C3a Antibody (354113) [Janelia Fluor® 549]

Application
Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Complement Component C3a

Complement Component C3a is an anaphylotoxin polypeptide that is proteolytically generated from C3. C3a formation is common to all three pathways of complement activation: classical (antibody-mediated), lectin and alternative. It binds C3a R on myeloid peripheral blood leukocytes, activated lymphocytes, endothelial and internal organ epithelial cells. It activates mast cells, neutrophils, and macrophages, enhances Th2 inflammatory reactions, promotes Th1 cell maturation, and inhibits Treg differentiation. It also stimulates leukocyte chemotaxis and smooth muscle contraction. Removal of the C-terminal arginine generates C3adesArg/ASP that binds the C5L2 receptor (GPR77) and stimulates triglyceride synthesis in adipocytes.

Alternate Names

Anaphylatoxin, C3

Gene Symbol

C3

Additional Complement Component C3a Products

Product Documents for Complement Component C3a Antibody (354113) [Janelia Fluor® 549]

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for Complement Component C3a Antibody (354113) [Janelia Fluor® 549]



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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