Catalog Number: 5320
Alternate Names: Carbon monoxide releasing molecule 3
Chemical Name: Tricarbonylchloro(glycinato)ruthenium
Biological Activity
Water-soluble carbon monoxide-releasing molecule. Suppresses thrombin-induced nitrite release in BV-2 microglia. Protects isolated rats hearts from reperfusion damage in vitro and is cardioprotective in a rat myocardial infarction model in vivo. Also prolongs survival of transplanted hearts in mice. Exhibits anti-inflammatory and vasorelaxant effects.
Technical Data
  • M.Wt:
    294.61
  • Formula:
    C5H4ClNO5Ru
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Store at -20°C
  • CAS No:
    475473-26-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Modulation of thrombin-induced neuroinflammation in BV-2 microglia by carbon monoxide-releasing molecule 3.
    Bani-Hani et al.
    J.Pharmacol.Exp.Ther., 2006;318:1315
  2. Acute myocardial infarction in streptozotocin-induced hyperglycaemic rats: protection by a carbon monoxide-releasing molecule (CORM-3).
    Filippo et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 2012;385:137
  3. Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule.
    Clark et al.
    Circ.Res., 2003;93:e2
  4. Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule.
    Foresti et al.
    Br.J.Pharmacol., 2004;142:453
  5. Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages.
    Sawle et al.
    Br.J.Pharmacol., 2005;145:800

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