Chemical Name: Tricarbonylchloro(glycinato)ruthenium
Biological ActivityCORM 3 is a water-soluble carbon monoxide-releasing molecule. Suppresses thrombin-induced nitrite release in BV-2 microglia. Protects isolated rats hearts from reperfusion damage in vitro and is cardioprotective in a rat myocardial infarction model in vivo. Also prolongs survival of transplanted hearts in mice. Exhibits anti-inflammatory and vasorelaxant effects.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule.
Clark et al.
Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule.
Foresti et al.
Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages.
Sawle et al.
Modulation of thrombin-induced neuroinflammation in BV-2 microglia by carbon monoxide-releasing molecule 3.
Bani-Hani et al.
Acute myocardial infarction in streptozotocin-induced hyperglycaemic rats: protection by a carbon monoxide-releasing molecule (CORM-3).
Filippo et al.
Naunyn Schmiedebergs Arch.Pharmacol., 2012;385:137
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