Covidcil-19

Key Product Details

Product Description

Covidcil-19 binds to the revised attenuator hairpin structure of the SARS-CoV-2 frameshifting element (FSE) with high affinity (K_d = 11 nM). It stabilizes the hairpin's folded state and reduces frameshifting efficiency in cells. Covidcil-19 inhibits viral propagation and reduces viral infectivity by > 3.5 orders of magnitude.

Product Specifications for Covidcil-19

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Covidcil-19

The following data is based on the product molecular weight 294.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	33.98 mL	169.89 mL	339.78 mL
0.5 mM	6.80 mL	33.98 mL	67.96 mL
1 mM	3.40 mL	16.99 mL	33.98 mL
5 mM	0.68 mL	3.40 mL	6.80 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Giorgio New chemical modalities enabling specific RNA targeting and degradation: application to SARS-CoV-2 RNA. ACS Cent.Sci. 2020 PMID: 33140031
• Haniff Targeting the SARS-CoV-2 RNA genome with small molecule binders and ribonuclease targeting chimera (RIBOTAC) degraders. ACS Cent.Sci. 2020 PMID: 33140033

Product Documents for Covidcil-19