Chemical Name: N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride
Biological ActivitySelective, non-peptide CRF1 receptor antagonist (Ki values are 2.7 and > 10000 nM for CRF1 and CRF2 receptors respectively). Blocks CRF-induced adenylate cyclase activation (Ki = 3.7 nM) and attenuates activation of the HPA axis by CRF. Displays anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Comparison of the V1b antagonist, SSR149415, and the CRF1 antagonist, CP-154,526, in rodent models of anxiety and depression.
Hodgson et al.
A non peptidic cortico. releasing factor receptor antagonist attenuates fever and exhibits anxiolytic activity.
Lundkist et al.
CP-154,526: a potent and selective nonpeptide antagonist of cortico. releasing factor receptors.
Schulz et al.
Citation for CP 154526
The citations listed below are publications that use Tocris products. Selected citations for CP 154526 include:
1 Citation: Showing 1 - 1
CRF-R1 activation in the anterior-dorsal BNST induces maternal neglect in lactating rats via an HPA axis-independent central mechanism.
Authors: Klampfl Et al.
Biochem Biophys Res Commun 2016;64:89
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