CP 154526

Catalog # Availability Size / Price Qty
2779/10
2779/50
CP 154526 | CAS No. 257639-98-8 | CRF1 Receptor Antagonists
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Description: Selective, non-peptide CRF1 antagonist

Chemical Name: N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity

Selective, non-peptide CRF1 receptor antagonist (Ki values are 2.7 and > 10000 nM for CRF1 and CRF2 receptors respectively). Blocks CRF-induced adenylate cyclase activation (Ki = 3.7 nM) and attenuates activation of the HPA axis by CRF. Displays anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant.

Technical Data

M.Wt:
400.99
Formula:
C23H32N4.HCl
Solubility:
Soluble to 50 mM in DMSO and to 50 mM in ethanol
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
257639-98-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Comparison of the V1b antagonist, SSR149415, and the CRF1 antagonist, CP-154,526, in rodent models of anxiety and depression.
    Hodgson et al.
    Pharmacol.Biochem.Behav., 2007;86:431
  2. A non peptidic cortico. releasing factor receptor antagonist attenuates fever and exhibits anxiolytic activity.
    Lundkist et al.
    Eur.J.Pharmacol., 1996;309:195
  3. CP-154,526: a potent and selective nonpeptide antagonist of cortico. releasing factor receptors.
    Schulz et al.
    Proc.Natl.Acad.Sci.USA, 1996;93:10477

Product Datasheets

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Citation for CP 154526

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