Selective, non-peptide CRF1
receptor antagonist (Ki
values are 2.7 and > 10000 nM for CRF1
receptors respectively). Blocks CRF-induced adenylate cyclase activation (Ki
= 3.7 nM) and attenuates activation of the HPA axis by CRF. Displays anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant.
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A non peptidic corticotropin releasing factor receptor antagonist attenuates fever and exhibits anxiolytic activity.
Lundkist et al.
Comparison of the V1b antagonist, SSR149415, and the CRF1 antagonist, CP-154,526, in rodent models of anxiety and depression.
Hodgson et al.
CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors.
Schulz et al.
The citations listed below are publications that use Tocris products. Selected citations for CP 154526 include:
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