Potent and selective CRF1
receptor antagonist (Ki
values are 12 and >10000 nM for CRF1
receptors respectively). Attenuates CRF-induced activation of the HPA axis in vivo
following i.v. administration. Orally active.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
2-Aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing factor 1 antagonists.
Chen et al.
Structure of class B GPCR corticotropin-releasing factor receptor 1.
Hollenstein et al.
The citations listed below are publications that use Tocris products. Selected citations for CP 376395 hydrochloride include:
Showing Results 1 - 2 of 2