Catalog Number: 3212
Chemical Name: N-(1-Ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-4-pyridinamine hydrochloride
Biological Activity
Potent and selective CRF1 receptor antagonist (Ki values are 12 and >10000 nM for CRF1 and CRF2 receptors respectively). Attenuates CRF-induced activation of the HPA axis in vivo following i.v. administration. Orally active.
Technical Data
  • M.Wt:
    362.94
  • Formula:
    C21H30N2O.HCl
  • Solubility:
    Soluble to 50 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    1013933-37-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 2-Aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing factor 1 antagonists.
    Chen et al.
    J.Med.Chem., 2008;51:1385
  2. Structure of class B GPCR corticotropin-releasing factor receptor 1.
    Hollenstein et al.
    Nature, 2013;499:438
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CP 376395 hydrochloride include:

2 Citations: Showing 1 - 2
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  1. Conformational thermostabilisation of corticotropin releasing factor receptor 1.
    Authors: Kean Et al.
    Mol Pain 2015;5:11954
  2. Social stress and CRF-dopamine interactions in the VTA: role in long-term escalation of cocaine self-administration.
    Authors: Boyson Et al.
    J Neurosci 2014;34:6659

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