CP 424174

Key Product Details

Product Description

CP 424174 is an inhibitor of IL-1β post-translational processing (IC₅₀ = 210 nM). Inhibits the formation of mature IL-1β. Indirectly inhibits NLRP3. Active in vivo and orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for CP 424174

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CP 424174

The following data is based on the product molecular weight 452.99.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.21 mL	11.04 mL	22.08 mL
5 mM	0.44 mL	2.21 mL	4.42 mL
10 mM	0.22 mL	1.10 mL	2.21 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Baldwin Inhibiting the inflammasome: a chemical perspective. J.Med.Chem. 2016 PMID: 26422006
• Perregaux Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors. J.Pharmacol.Exp.Ther. 2001 PMID: 11561079

Product Documents for CP 424174