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CP 424174

Catalog #: 6107 Datasheet / COA / SDS

Discontinued Product

6107 has been discontinued.
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CP 424174 | CAS No. 210825-31-3 | Cytokine Compounds
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Description: Inhibitor of IL-1β post-translational processing; indirectly inhibits NLRP3

Chemical Name: N-[[[4-Chloro-2,6-bis(1-methylethyl)phenyl]amino]carbonyl]-3-(1-hydroxy-1-methylethyl)benzenesulfonamide

Purity: ≥98%

Product Details
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

CP 424174 is an inhibitor of IL-1β post-translational processing (IC50 = 210 nM). Inhibits the formation of mature IL-1β. Indirectly inhibits NLRP3. Active in vivo and orally bioavailable.

Technical Data

M.Wt:
452.99
Formula:
C22H29ClN2O4S
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
210825-31-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors.
    Perregaux et al.
    J.Pharmacol.Exp.Ther., 2001;299:187
  2. Inhibiting the inflammasome: a chemical perspective.
    Baldwin et al.
    J.Med.Chem., 2016;59:1691

Product Datasheets

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