Catalog Number: 6107
Chemical Name: N-[[[4-Chloro-2,6-bis(1-methylethyl)phenyl]amino]carbonyl]-3-(1-hydroxy-1-methylethyl)benzenesulfonamide
Biological Activity
Inhibitor of IL-1β post-translational processing (IC50 = 210 nM). Inhibits the formation of mature IL-1β. Indirectly inhibits NLRP3. Active in vivo and orally bioavailable.
Technical Data
  • M.Wt:
    452.99
  • Formula:
    C22H29ClN2O4S
  • Solubility:
    Soluble to 100 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    210825-31-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors.
    Perregaux et al.
    J.Pharmacol.Exp.Ther., 2001;299:187
  2. Inhibiting the inflammasome: a chemical perspective.
    Baldwin et al.
    J.Med.Chem., 2016;59:1691
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