Inhibitor of IL-1β
post-translational processing (IC50
= 210 nM). Inhibits the formation of mature IL-1β
. Indirectly inhibits NLRP3. Active in vivo
and orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold for research purposes under agreement from Pfizer Inc.
Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors.
Perregaux et al.
Inhibiting the inflammasome: a chemical perspective.
Baldwin et al.