CP 43

Key Product Details

Product Description

CP 43 is a potent TAO kinase (TAOK) inhibitor (IC₅₀ values are 11 nM/L and 15 nM/L for TAOK1 and TAOK2, respectively). Inhibits TAOK phosphorylation and activation of JNK in vitro. Prolongs duration of mitosis and increases mitotic cell death in the SKBR3 breast cancer cell line. Also reduces tau phopshorylation in cortical neurons at sites associated with neurodegeneration in human tauopathies.

Product Specifications for CP 43

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CP 43

The following data is based on the product molecular weight 384.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.60 mL	13.00 mL	26.01 mL
5 mM	0.52 mL	2.60 mL	5.20 mL
10 mM	0.26 mL	1.30 mL	2.60 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Giacomini A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies. Acta Neuropathol.Commun. 2018 PMID: 29730992
• Koo Targeting TAO kinase using a new inhibitor compound delays mitosis and induces mitotic cell death in centrosome amplified breast cancer cells. Mol.Cancer Ther. 2017 PMID: 28830982

Product Documents for CP 43