CP 43

Catalog # Availability Size / Price Qty
6558/10
6558/50
Cat.No. 6558 - CP 43 | C25H24N2O2 | CAS No. 850467-66-2
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Description: Potent TAOK inhibitor

Chemical Name: N-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide

Purity: ≥98%

Product Details
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Biological Activity

Potent TAO kinase (TAOK) inhibitor (IC50 values are 11 nM/L and 15 nM/L for TAOK1 and TAOK2, respectively). Inhibits TAOK phosphorylation and activation of JNK in vitro. Prolongs duration of mitosis and increases mitotic cell death in the SKBR3 breast cancer cell line. Also reduces tau phopshorylation in cortical neurons at sites associated with neurodegeneration in human tauopathies.

Technical Data

M.Wt:
384.47
Formula:
C25H24N2O2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at RT
CAS No:
850467-66-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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