CP 465022 hydrochloride

Key Product Details

Product Description

CP 465022 hydrochloride is a selective, non-competitive AMPA antagonist (IC₅₀ = 25 nM in rat cortical neurons) that displays potent anticonvulsant activity. Also significantly blocks the persistent component of Na_v1.6 channel activity. Brain penetrant and orally active.

Product Specifications for CP 465022 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CP 465022 hydrochloride

The following data is based on the product molecular weight 499.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.00 mL	10.01 mL	20.02 mL
5 mM	0.40 mL	2.00 mL	4.00 mL
10 mM	0.20 mL	1.00 mL	2.00 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Menniti CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA receptors but is not neuroprotective in vivo. Stroke 2003 PMID: 12511770
• Welch Traditional AMPA receptor antagonists partially block Na_v1.6-mediated persistent current. Neuropharmacology 2008 PMID: 18687344
• Lazaro Functional characterization of CP-465,022, a selective, noncompetitive AMPA receptor antagonist. Neuropharmacology 2002 PMID: 11804610

Product Documents for CP 465022 hydrochloride