Catalog Number: 2932
Chemical Name: 3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinone hydrochloride
Biological Activity
Selective, non-competitive AMPA antagonist (IC50 = 25 nM in rat cortical neurons) that displays potent anticonvulsant activity. Also significantly blocks the persistent component of Nav1.6 channel activity. Brain penetrant and orally active.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Functional characterization of CP-465,022, a selective, noncompetitive AMPA receptor antagonist.
    Lazaro et al.
    Neuropharmacology, 2002;42:143
  2. CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA receptors but is not neuroprotective in vivo.
    Menniti et al.
    Stroke, 2003;34:171
  3. Traditional AMPA receptor antagonists partially block Nav1.6-mediated persistent current.
    Welch et al.
    Neuropharmacology, 2008;55:1165
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