CP 673451

Catalog # Availability Size / Price Qty
CP 673451 | CAS No. 343787-29-1 | PDGF Receptor Inhibitors
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Description: Potent and selective PDGFR inhibitor

Chemical Name: 1-[2-[5-(2-Methoxyethoxy)-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine

Purity: ≥98%

Product Details
Supplemental Products

Biological Activity

CP 673451 is a potent and selective PDGFR inhibitor (IC50 values are 1 and 10 nM for PDGFR-β and -α respectively). Selective for PDGFR kinase over a range of related kinases. Inhibits PDGFR-β phosphorylation in glioblastoma xenografts and PDGF-induced angiogenesis in mice.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CP 673451 is reviewed on the Chemical Probes website.

Technical Data

Soluble to 20 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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