CP 673451

Key Product Details

Product Description

CP 673451 is a potent and selective PDGFR inhibitor (IC₅₀ values are 1 and 10 nM for PDGFR-β and -α respectively). Selective for PDGFR kinase over a range of related kinases. Inhibits PDGFR-β phosphorylation in glioblastoma xenografts and PDGF-induced angiogenesis in mice.

External Portal Information

Chemicalprobes.org

is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CP 673451 is reviewed on the Chemical Probes website.

Product Specifications for CP 673451

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CP 673451

The following data is based on the product molecular weight 417.50.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

3 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.98 mL	59.88 mL	119.76 mL
1 mM	2.40 mL	11.98 mL	23.95 mL
2 mM	1.20 mL	5.99 mL	11.98 mL
10 mM	0.24 mL	1.20 mL	2.40 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

• Roberts Antiangiogenic and antitumor activity of a selective PDGFR tyrosine kinase inhibitor, CP-673,451. Cancer Res. 2005 PMID: 15705896

Product Documents for CP 673451