Chemical Name: 1-[2-[5-(2-Methoxyethoxy)-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine
Biological ActivityCP 673451 is a potent and selective PDGFR inhibitor (IC50 values are 1 and 10 nM for PDGFR-β and -α respectively). Selective for PDGFR kinase over a range of related kinases. Inhibits PDGFR-β phosphorylation in glioblastoma xenografts and PDGF-induced angiogenesis in mice.
External Portal InformationChemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CP 673451 is reviewed on the Chemical Probes website.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Antiangiogenic and antitumor activity of a selective PDGFR tyrosine kinase inhibitor, CP-673,451.
Roberts et al.
Cancer Res., 2005;65:957
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VersaClone cDNA Plasmids
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