CP 93129 dihydrochloride
Chemical Name: 1,4-Dihydro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-5H-pyrrol[3,2-b]pyridin-5-one dihydrochloride
Biological ActivityPotent and highly selective 5-HT1B agonist (Ki values are 8.1, 1100, 1500, 2900 and 7200 nM for 5-HT1B, 5-HT1D, 5-HT1A, 5-HT1c and 5-HT2, respectively). Reduces food intake and decreases body weight in rats.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253.
Koe et al.
Drug Development Research, 1992;26:241
Modulation of neurotransmission by GPCRs is dependent upon the microarchitecture of the primed vesicle complex.
Hamid et al.
J Neurosci., 2014;34:260
Infusion of the serotonin1B (5-HT1B) agonist CP-93,129 into the parabrachial nucleus potently and selectively reduces food intake in rats.
Lee et al.
Citations for CP 93129 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for CP 93129 dihydrochloride include:
9 Citations: Showing 1 - 9
Modulation of Kalirin-7 Expression by Hippocampal CA1 5-HT1B Receptors in Spatial Memory Consolidation.
Authors: Zhou Et al.
Behav Brain Res 2019;356:148
Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus.
Authors: Medrihan Et al.
Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells.
Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster.
Authors: Majeed Et al.
Neural Plast 2016;2016:7291438
5-HT is a potent relaxant in rat superior mesenteric veins.
Authors: Watts Et al.
Cereb Cortex 2015;3:e00103
Presynaptic 5-HT(1B) receptor-mediated serotonergic inhibition of glutamate transmission in the bed nucleus of the stria terminalis.
Authors: Guo and Rainnie
Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responses.
Authors: Watakabe Et al.
Serotonin reciprocally regulates melanocortin neurons to modulate food intake.
Authors: Heisler Et al.
J Pharmacol Exp Ther 2006;51:239
Methamphetamine administration reduces hippocampal vesicular monoamine transporter-2 uptake.
Authors: Rau Et al.
Exp Ther Med 2006;318:676
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