CP 93129 dihydrochloride

Catalog # Availability Size / Price Qty
1032/10
1032/50
CP 93129 dihydrochloride | CAS No. 879089-64-2 | 5-HT1B Receptor Agonists
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Description: 5-HT1B agonist

Chemical Name: 1,4-Dihydro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-5H-pyrrol[3,2-b]pyridin-5-one dihydrochloride

Product Details
Citations (9)
Supplemental Products
Reviews (1)

Biological Activity

Potent and highly selective 5-HT1B agonist (Ki values are 8.1, 1100, 1500, 2900 and 7200 nM for 5-HT1B, 5-HT1D, 5-HT1A, 5-HT1c and 5-HT2, respectively). Reduces food intake and decreases body weight in rats.

Technical Data

M.Wt:
288.18
Formula:
C12H13N3O.2HCl
Solubility:
Soluble to 100 mM in water
Storage:
Desiccate at RT
CAS No:
879089-64-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253.
    Koe et al.
    Drug Development Research, 1992;26:241
  2. Modulation of neurotransmission by GPCRs is dependent upon the microarchitecture of the primed vesicle complex.
    Hamid et al.
    J Neurosci., 2014;34:260
  3. Infusion of the serotonin1B (5-HT1B) agonist CP-93,129 into the parabrachial nucleus potently and selectively reduces food intake in rats.
    Lee et al.
    Psychopharmacology, 1998;136:304

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Citations for CP 93129 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for CP 93129 dihydrochloride include:

9 Citations: Showing 1 - 9

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Antidepressantsby Cholecystokinin Neurons of the Dentate Gyrus
By Anonymous on 02/03/2020
Species: Mouse

CP (10mM)

PMID: 28735749

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