CP 93129 dihydrochloride

  ( 7 citations )    
Product Datasheet
Catalog Number:1032
Chemical Name:1,4-Dihydro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-5H-pyrrol[3,2-b]pyridin-5-one dihydrochloride
Product Details
Citations (7)
Supplemental Products
Reviews
Biological Activity
Potent and highly selective 5-HT1B agonist (Ki values are 8.1, 1100, 1500, 2900 and 7200 nM for 5-HT1B, 5-HT1D, 5-HT1A, 5-HT1c and 5-HT2, respectively). Reduces food intake and decreases body weight in rats.
Technical Data
  • M.Wt:
    288.18
  • Formula:
    C12H13N3O.2HCl
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Desiccate at RT
  • CAS No:
    879089-64-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CP 93129 dihydrochloride include:

7 Citations: Showing 1 - 7
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  1. Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells.
    Authors: Hirono
    Neuropharmacology  2017;118:79
  2. Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster.
    Authors: Majeed Et al.
    Neural Plast  2016;2016:7291438
  3. 5-HT is a potent relaxant in rat superior mesenteric veins.
    Authors: Watts Et al.
    Cereb Cortex  2015;3:e00103
  4. Presynaptic 5-HT(1B) receptor-mediated serotonergic inhibition of glutamate transmission in the bed nucleus of the stria terminalis.
    Authors: Guo and Rainnie
    Neuroscience  2010;165:1390
  5. Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responses.
    Authors: Watakabe Et al.
    Neuron  2009;19:1915
  6. Serotonin reciprocally regulates melanocortin neurons to modulate food intake.
    Authors: Heisler Et al.
    J Pharmacol Exp Ther  2006;51:239
  7. Methamphetamine administration reduces hippocampal vesicular monoamine transporter-2 uptake.
    Authors: Rau Et al.
    Exp Ther Med  2006;318:676

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