Catalog Number: 1032
Chemical Name: 1,4-Dihydro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-5H-pyrrol[3,2-b]pyridin-5-one dihydrochloride
Biological Activity
Potent and highly selective 5-HT1B agonist (Ki values are 8.1, 1100, 1500, 2900 and 7200 nM for 5-HT1B, 5-HT1D, 5-HT1A, 5-HT1c and 5-HT2, respectively). Reduces food intake and decreases body weight in rats.
Technical Data
  • M.Wt:
    288.18
  • Formula:
    C12H13N3O.2HCl
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Desiccate at RT
  • CAS No:
    879089-64-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. Modulation of neurotransmission by GPCRs is dependent upon the microarchitecture of the primed vesicle complex.
    Hamid et al.
    J Neurosci., 2014;34:260
  2. Infusion of the serotonin1B (5-HT1B) agonist CP-93,129 into the parabrachial nucleus potently and selectively reduces food intake in rats.
    Lee et al.
    Psychopharmacology, 1998;136:304
  3. Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253.
    Koe et al.
    Drug Development Research, 1992;26:241
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CP 93129 dihydrochloride include:

5 Citations: Showing 1 - 5
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  1. Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells.
    Authors: Hirono
    Neuropharmacology 2017;118:79
  2. 5-HT is a potent relaxant in rat superior mesenteric veins.
    Authors: Watts Et al.
    Cereb Cortex 2015;3:e00103
  3. Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responses.
    Authors: Watakabe Et al.
    Neuron 2009;19:1915
  4. Serotonin reciprocally regulates melanocortin neurons to modulate food intake.
    Authors: Heisler Et al.
    J Pharmacol Exp Ther 2006;51:239
  5. Methamphetamine administration reduces hippocampal vesicular monoamine transporter-2 uptake.
    Authors: Rau Et al.
    Exp Ther Med 2006;318:676

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