CP 94253 hydrochloride

Tocris Bioscience | Catalog # 1317

Potent and selective 5-HT1B agonist
Tocris Bioscience

Key Product Details

Description

Potent and selective 5-HT1B agonist
View all 5-HT1B Receptor Agonists »

Product Description

CP 94253 hydrochloride is a potent, selective 5-HT1B agonist (Ki values are 89, 2, 860, 49 and 1,600 nM for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D and 5-HT2 receptors respectively). Centrally active upon systemic administration in vivo.

Product Specifications for CP 94253 hydrochloride

Molecular Weight

293.80

Formula

C15H19N3O.HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

5-Propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-pyrrolo[3,2-b]pyridine hydrochloride

CAS Number

845861-39-4

PubChem ID

11652258

InChI Key

PIIOXKQIZCVXMD-UHFFFAOYSA-N

SMILES

Cl.CCCOC1=CC=C2NC=C(C2=N1)C1=CCNCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 7.34 25
DMSO 29.38 100

Preparing Stock Solutions for CP 94253 hydrochloride

The following data is based on the product molecular weight 293.80.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.40 mL 17.02 mL 34.04 mL
5 mM 0.68 mL 3.40 mL 6.81 mL
10 mM 0.34 mL 1.70 mL 3.40 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

Product Documents for CP 94253 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CP 94253 hydrochloride

For research use only

Citations for CP 94253 hydrochloride

Customer Reviews for CP 94253 hydrochloride (1)

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  • CP-94253 reduces food intake in obese mice
    Name: Sergiy Sylantyev
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 12/10/2023
    CP-94253 was used to test an impact of 5HT-1B receptor on feeding behaviour in mice. Illustration: CP-94253 (16 mg/kg i.p.) significantly decreased high fat diet intake in obese mice compared to saline treatment. Repeated measures ANOVA followed by Dunnett’s post hoc tests, * - P<0.05, ** - P<0.01.
    CP 94253 hydrochloride 1317

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