CP 94253 hydrochloride (CAS 845861-39-4): R&D Systems
Catalog Number: 1317
Chemical Name: 5-Propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-pyrrolo[3,2-b]pyridine hydrochloride
Biological Activity
Potent, selective 5-HT1B agonist (Ki values are 89, 2, 860, 49 and 1,600 nM for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D and 5-HT2 receptors respectively). Centrally active upon systemic administration in vivo.
Technical Data
  • M.Wt:
    293.8
  • Formula:
    C15H19N3O.HCl
  • Solubility:
    Soluble to 25 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    845861-39-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Aggression heightened by alcohol or social instigation in mice: reduction by the 5-HT(1B) receptor agonist CP-94,253.
    Fish et al.
    Psychopharmacology, 1999;146:391
  2. Regulation of extracellular concentrations of 5-hydroxytryptamine (5-HT) in mouse striatum by 5-HT1A and 5-HT1B receptors.
    Knobelman et al.
    J.Pharmacol.Exp.Ther., 2000;292:1111
  3. Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253.
    Koe et al.
    Drug Development Research, 1992;26:241
Citations:

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