CP 945598 hydrochloride

Key Product Details

Product Description

CP 945598 hydrochloride is a selective, high affinity CB₁ antagonist (K_i values are 0.7 and 0.12 nM in binding and functional assays respectively). Displays low affinity for CB₂ receptors (K_i = 7600 nM).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for CP 945598 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CP 945598 hydrochloride

The following data is based on the product molecular weight 546.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	9.14 mL	45.71 mL	91.43 mL
1 mM	1.83 mL	9.14 mL	18.29 mL
2 mM	0.91 mL	4.57 mL	9.14 mL
10 mM	0.18 mL	0.91 mL	1.83 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Hadcock In vitro and in vivo pharmacology of CP-945,598, a potent and selective cannabinoid CB₁ receptor antagonist for the management of obesity. Biochem.Biophys.Res.Commun. 2010 PMID: 20211605
• Griffith Discovery of 1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic acid amide hydrochloride (CP-945,598), a novel, potent, and selective cannabinoid type 1 receptor antagonist. J.Med.Chem. 2009 PMID: 19102698

Product Documents for CP 945598 hydrochloride