Catalog Number: 3417
Chemical Name: (2S,3S)-N-[(2-Methoxyphenyl)methyl]-2-phenyl-3-piperidinamine dihydrochloride
Biological Activity
High affinity NK1 antagonist (Ki = 0.145 nM in vitro). Also displays high ex vivo binding potency in gerbil striatum (IC50 = 36.8 nM). Attenuates endothelium-dependent contraction induced by substance P.
Technical Data
  • M.Wt:
    369.33
  • Formula:
    C19H24N2O.2HCl
  • Solubility:
    Soluble to 100 mM in water and to 50 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    145148-39-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. Endothelium-dependent contraction in intrapulmonary arteries: mediation by endothelial NK1 receptors and TXA2.
    Shirahase et al.
    Br.J.Pharmacol., 1995;115:1215
  2. Correlation of neurokinin (NK) 1 receptor occupancy in gerbil striatum with behavioral effects of NK1 antagonists.
    Duffy et al.
    J.Pharmacol.Exp.Ther., 2002;301:536
  3. Neurokinin 1 receptor antagonists: correlation between in vitro receptor interaction and in vivo efficacy.
    Lindstrom et al.
    J.Pharmacol.Exp.Ther., 2007;322:1286
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CP 99994 dihydrochloride include:

1 Citations: Showing 1 - 1

  1. Novel dynamic measures of emetic behavior in musk shrews.
    Authors: Horn Et al.
    Nature 2013;179:60

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