CP 99994 dihydrochloride

Key Product Details

Product Description

CP 99994 dihydrochloride is a high affinity NK₁ antagonist (K_i = 0.145 nM in vitro). Also displays high ex vivo binding potency in gerbil striatum (IC₅₀ = 36.8 nM). Attenuates endothelium-dependent contraction induced by substance P.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for CP 99994 dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CP 99994 dihydrochloride

The following data is based on the product molecular weight 369.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.71 mL	13.54 mL	27.08 mL
5 mM	0.54 mL	2.71 mL	5.42 mL
10 mM	0.27 mL	1.35 mL	2.71 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Duffy Correlation of neurokinin (NK) 1 receptor occupancy in gerbil striatum with behavioral effects of NK1 antagonists. J.Pharmacol.Exp.Ther. 2002 PMID: 11961054
• Lindstrom Neurokinin 1 receptor antagonists: correlation between in vitro receptor interaction and in vivo efficacy. J.Pharmacol.Exp.Ther. 2007 PMID: 17575073
• Shirahase Endothelium-dependent contraction in intrapulmonary arteries: mediation by endothelial NK₁ receptors and TXA₂. Br.J.Pharmacol. 1995 PMID: 7582548

Product Documents for CP 99994 dihydrochloride