CP 99994 dihydrochloride
Chemical Name: (2S,3S)-N-[(2-Methoxyphenyl)methyl]-2-phenyl-3-piperidinamine dihydrochloride
Biological ActivityCP 99994 dihydrochloride is a high affinity NK1 antagonist (Ki = 0.145 nM in vitro). Also displays high ex vivo binding potency in gerbil striatum (IC50 = 36.8 nM). Attenuates endothelium-dependent contraction induced by substance P.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Endothelium-dependent contraction in intrapulmonary arteries: mediation by endothelial NK1 receptors and TXA2.
Shirahase et al.
Correlation of neurokinin (NK) 1 receptor occupancy in gerbil striatum with behavioral effects of NK1 antagonists.
Duffy et al.
Neurokinin 1 receptor antagonists: correlation between in vitro receptor interaction and in vivo efficacy.
Lindstrom et al.
Citations for CP 99994 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for CP 99994 dihydrochloride include:
7 Citations: Showing 1 - 7
Role of perivascular nerve and sensory neurotransmitter dysfunction in inflammatory bowel disease.
Authors: Craig L Et al.
Am J Physiol Heart Circ Physiol 2021;320:H1887-H1902
nNOS-expressing interneurons control basal and behaviorally evoked arterial dilation in somatosensory cortex of mice.
Authors: Christina T Et al.
The neurokinin-1 receptor is expressed with gastrin-releasing peptide receptor in spinal interneurons and modulates itch.
Authors: Sheahan Et al.
N-benzhydryl quinuclidine compounds are a potent and Src kinase-independent inhibitor of NALCN channels.
Authors: Suyun Et al.
Br J Pharmacol 2020;177:3795-3810
Crystal structure of the human NK1 tachykinin receptor.
Authors: Yin Et al.
Differential Gene Expression Profile in the Rat Caudal Vestibular Nucleus is Associated with Individual Differences in Motion Sickness Susceptibility.
Authors: Wei Et al.
PLoS One 2015;10:e0124203
Novel dynamic measures of emetic behavior in musk shrews.
Authors: Horn Et al.
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