High affinity NK1
= 0.145 nM in vitro
). Also displays high ex vivo
binding potency in gerbil striatum (IC50
= 36.8 nM). Attenuates endothelium-dependent contraction induced by substance P.
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Endothelium-dependent contraction in intrapulmonary arteries: mediation by endothelial NK1 receptors and TXA2.
Shirahase et al.
Correlation of neurokinin (NK) 1 receptor occupancy in gerbil striatum with behavioral effects of NK1 antagonists.
Duffy et al.
Neurokinin 1 receptor antagonists: correlation between in vitro receptor interaction and in vivo efficacy.
Lindstrom et al.
The citations listed below are publications that use Tocris products. Selected citations for CP 99994 dihydrochloride include:
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