Biological Activity Potent inhibitor of c-MET and anaplastic lymphoma kinase (ALK) (cell IC50 values are 8.0 and 20 nM respectively). Selective for c-MET and ALK against >120 different kinases. Displays antitumor efficacy in multiple tumor models; inhibits c-MET-dependent proliferation, migration and invasion of human tumor cells in vitro. Orally bioavailable.
Soluble to 10 mM in DMSO and to 100 mM in 2eq.HCl
Store at +4°C
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For batch specific data refer to the Certificate of Analysis.
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