Crizotinib

Catalog # Availability Size / Price Qty
4368/10
4368/50
Description: Potent c-MET/ALK inhibitor
Alternative Names: PF 02341066, PF 2341066

Chemical Name: 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine

Purity: ≥99%

Product Details
Citations (4)
Supplemental Products
Reviews

Biological Activity

Potent inhibitor of c-MET and anaplastic lymphoma kinase (ALK) (cell IC50 values are 8.0 and 20 nM respectively). Selective for c-MET and ALK against >120 different kinases. Displays antitumor efficacy in multiple tumor models; inhibits c-MET-dependent proliferation, migration and invasion of human tumor cells in vitro. Orally bioavailable.

Technical Data

M.Wt:
450.34
Formula:
C21H22Cl2FN5O
Solubility:
Soluble to 10 mM in DMSO and to 100 mM in 2eq.HCl
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
877399-52-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Product Datasheets

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Citations for Crizotinib

The citations listed below are publications that use Tocris products. Selected citations for Crizotinib include:

4 Citations: Showing 1 - 4

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