Catalog Number: 4368
Alternate Names: PF 02341066, PF 2341066
Chemical Name: 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine
Biological Activity
Potent inhibitor of c-MET and anaplastic lymphoma kinase (ALK) (cell IC50 values are 8.0 and 20 nM respectively). Selective for c-MET and ALK against >120 different kinases. Displays antitumor efficacy in multiple tumor models; inhibits c-MET-dependent proliferation, migration and invasion of human tumor cells in vitro. Orally bioavailable.
Technical Data
  • M.Wt:
    450.34
  • Formula:
    C21H22Cl2FN5O
  • Solubility:
    Soluble to 10 mM in DMSO and to 100 mM in 2eq.HCl
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    877399-52-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Crizotinib include:

3 Citations: Showing 1 - 3
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  1. Crizotinib, a MET inhibitor, inhibits growth, migration, and invasion of breast cancer cells in vitro and synergizes with chemotherapeutic agents.
    Authors: Ayoub
    Onco Targets Ther 2017;10:4869
  2. ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53.
    Authors: Sullivan Et al.
    FASEB J 2012;8:646
  3. Multiple mutations and bypass mechanisms can contribute to development of acquired resistance to MET inhibitors.
    Authors: Qi Et al.
    Cancer Res 2011;71:1081

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