( 6 citations )    
Product Datasheet
Catalog Number:1377
Alternate Names:BRL 34915
Chemical Name:trans-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile
Product Details
Citations (6)
Supplemental Products
Biological Activity
Prototypical Kir6 (KATP) channel opener. Relaxes rabbit isolated portal vein with an IC50 value of 21 nM. Potent, orally active and hypotensive in vivo.

Active Enantiomer also available.

Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license
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Product Datasheets

The citations listed below are publications that use Tocris products. Selected citations for Cromakalim include:

6 Citations: Showing 1 - 6
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  1. Antidiarrhoeal, antisecretory and antispasmodic activities of Matricaria chamomilla are mediated predominantly through K(+)-channels activation.
    Authors: Mehmood Et al.
    PLoS One  2015;15:75
  2. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes.
    Authors: Seto Et al.
    Am J Physiol Heart Circ Physiol  2013;8:e66404
  3. The sGC activator BAY 60-2770 has potent erectile activity in the rat.
    Authors: Lasker Et al.
    Am J Physiol Heart Circ Physiol  2013;304:H1670
  4. Involvement of the NO-cGMP-K(ATP) channel pathway in the mesenteric lymphatic pump dysfunction observed in the guinea pig model of TNBS-induced ileitis.
    Authors: Mathias and Weid
    Am J Physiol Gastrointest Liver Physiol  2013;304:G623
  5. Impaired vascular responses of insulin-resistant rats after mild subarachnoid hemorrhage.
    Authors: Institóris Et al.
    PLoS One  2011;300:H2080
  6. Alterations in KATP and KCa channel function in cerebral arteries of insulin-resistant rats.
    Authors: Erdos Et al.
    Am J Physiol Heart Circ Physiol  2002;283:H2472


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