Catalog Number: 1377
Alternate Names: BRL 34915
Chemical Name: trans-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile
Biological Activity
Prototypical Kir6 (KATP) channel opener. Relaxes rabbit isolated portal vein with an IC50 value of 21 nM. Potent, orally active and hypotensive in vivo.

Active Enantiomer also available.

Technical Data
  • M.Wt:
    286.33
  • Formula:
    C16H18N2O3
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    94470-67-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license
Other Product-Specific Information:
Background References
  1. The potassium channel opener cromakalim (BRL 34915) activates ATP-dependent K+ channels in isolated cardiac myocytes.
    Escande et al.
    Biochem.Biophys.Res.Commun., 1988;154:620
  2. Cromakalim, a potassium channel activator: a comparison of its cardiovascular haemodynamic profile and tissue specificity with those of pinacidil and nicorandil.
    Longman et al.
    J.Cardiovasc.Pharmacol., 1988;12:535
  3. Comparative effects of K+ channel blockade on the vasorelaxant activity of cromakalim, pinacidil and nicorandil.
    Wilson et al.
    Eur.J.Pharmacol., 1988;152:331
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Cromakalim include:

4 Citations: Showing 1 - 4
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  1. Antidiarrhoeal, antisecretory and antispasmodic activities of Matricaria chamomilla are mediated predominantly through K(+)-channels activation.
    Authors: Mehmood Et al.
    PLoS One 2015;15:75
  2. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes.
    Authors: Seto Et al.
    Am J Physiol Heart Circ Physiol 2013;8:e66404
  3. The sGC activator BAY 60-2770 has potent erectile activity in the rat.
    Authors: Lasker Et al.
    Am J Physiol Heart Circ Physiol 2013;304:H1670
  4. Impaired vascular responses of insulin-resistant rats after mild subarachnoid hemorrhage.
    Authors: Institóris Et al.
    PLoS One 2011;300:H2080
Tocris Small Molecules
Description Application Cat# Citations Images  

Levcromakalim

1378 1  
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