Cromakalim

Tocris Bioscience | Catalog # 1377

Kir6 (KATP) channel opener
Tocris Bioscience
Discontinued Product
1377 has been discontinued. View all Inward Rectifier Potassium Channel Activators products.

Key Product Details

Description

Kir6 (KATP) channel opener

Alternative Names

BRL 34915
View all Inward Rectifier Potassium Channel Activators »

Product Description

Cromakalim is a prototypical Kir6 (KATP) channel opener. Relaxes rabbit isolated portal vein with an IC50 value of 21 nM. Potent, orally active and hypotensive in vivo.

Active Enantiomer also available.

Licensing Information

Sold under license

Product Specifications for Cromakalim

Molecular Weight

286.33

Formula

C16H18N2O3

Storage

Store at RT

Purity

≥99% (HPLC)

Chemical Name

trans-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile

CAS Number

94470-67-4

PubChem ID

76968376

InChI Key

BVMDRSUIADWFLV-PNSAJKJISA-N

SMILES

O=C1CCCN1[C@H]2[C@H](O)C(C)(C)OC3=C2C=C(C#N)C=C3.O=C4CCCN4[C@@H]5[C@@H](O)C(C)(C)OC6=C5C=C(C#N)C=C6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20

Preparing Stock Solutions for Cromakalim

The following data is based on the product molecular weight 286.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 17.46 mL 87.31 mL 174.62 mL
1 mM 3.49 mL 17.46 mL 34.92 mL
2 mM 1.75 mL 8.73 mL 17.46 mL
10 mM 0.35 mL 1.75 mL 3.49 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 26 publications citing the usage of this product.

Product Documents for Cromakalim

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Cromakalim

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for Cromakalim (1)

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  • Cromakalim used to study BK channel modulation
    Name: Sadequl Islam
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 11/27/2018
    Cromakalim was used to assess the channel opening properties when used on cell line that express BK channels. Gives consistent result that is reproducible.
    Cromakalim 1377

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