CRT 0066101

  ( 2 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:4975
Chemical Name:2-[4-[[(2R)-2-aminobutyl]amino]-2-pyrimidinyl]-4-(1-methyl-1H-pyrazol-4-yl)phenol dihydrochloride
Product Details
Citations (2)
Reviews
Biological Activity
Potent inhibitor of protein kinase D (PKD); inhibits all PKD isoforms (IC50 values are 1, 2 and 2.5 nM for PKD1, PKD3 and PKD2 respectively). Exhibits selectivity for PKD against a panel of >90 protein kinases, including PKCα, MEK, ERK, c-Raf and c-Src. Reduces proliferation and cell viability of pancreatic cancer cells expressing moderate levels of endogenous PKD1/2. Orally bioavailable.
Technical Data
  • M.Wt:
    411.33
  • Formula:
    C18H22N6O.2HCl
  • Solubility:
    Soluble to 100 mM in water and to 20 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    1883545-60-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for CRT 0066101 include:

2 Citations: Showing 1 - 2
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  1. Protein kinase D and Gβγ subunits mediate agonist-evoked translocation of protease-activated receptor-2 from the Golgi apparatus to the plasma membrane.
    Authors: Jensen Et al.
    J.Biol.Chem.  2016;291:11285
  2. Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia.
    Authors: Liou Et al.
    Sci Rep  2015;6:6200

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Average Rating: 5 (Based on 1 review)

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Summary

Species Mouse

Other Experimental Details

Other Experimental Details the CRT0066101 PKD inhibitor can be dissolved in normal saline or DMSO easily (depends of the concentration)

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