CRT 0066101

Catalog # Availability Size / Price Qty
4975/10
CRT 0066101 | CAS No. 1883545-60-5 | Protein Kinase D Inhibitors
1 Image
Description: Potent protein kinase D (PKD) inhibitor

Chemical Name: 2-[4-[[(2R)-2-aminobutyl]amino]-2-pyrimidinyl]-4-(1-methyl-1H-pyrazol-4-yl)phenol dihydrochloride

Purity: ≥98%

Product Details
Citations (3)
Reviews

Biological Activity

CRT 0066101 is a potent inhibitor of protein kinase D (PKD); inhibits all PKD isoforms (IC50 values are 1, 2 and 2.5 nM for PKD1, PKD3 and PKD2 respectively). Exhibits selectivity for PKD against a panel of >90 protein kinases, including PKCα, MEK, ERK, c-Raf and c-Src. Reduces proliferation and cell viability of pancreatic cancer cells expressing moderate levels of endogenous PKD1/2. Orally bioavailable.

Technical Data

M.Wt:
411.33
Formula:
C18H22N6O.2HCl
Solubility:
Soluble to 100 mM in water and to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1883545-60-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for CRT 0066101

The citations listed below are publications that use Tocris products. Selected citations for CRT 0066101 include:

3 Citations: Showing 1 - 3

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for CRT 0066101

There are currently no reviews for this product. Be the first to review CRT 0066101 and earn rewards!

Have you used CRT 0066101?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.