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CRT 0066101

Catalog #: 4975
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4975/10
CRT 0066101 | CAS No. 1883545-60-5 | Protein Kinase D Inhibitors
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Description: Potent protein kinase D (PKD) inhibitor

Chemical Name: 2-[4-[[(2R)-2-aminobutyl]amino]-2-pyrimidinyl]-4-(1-methyl-1H-pyrazol-4-yl)phenol dihydrochloride

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

CRT 0066101 is a potent inhibitor of protein kinase D (PKD); inhibits all PKD isoforms (IC50 values are 1, 2 and 2.5 nM for PKD1, PKD3 and PKD2 respectively). Exhibits selectivity for PKD against a panel of >90 protein kinases, including PKCα, MEK, ERK, c-Raf and c-Src. Reduces proliferation and cell viability of pancreatic cancer cells expressing moderate levels of endogenous PKD1/2. Orally bioavailable.

Technical Data

M.Wt:
411.33
Formula:
C18H22N6O.2HCl
Solubility:
Soluble to 100 mM in water and to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1883545-60-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for CRT 0066101

The citations listed below are publications that use Tocris products. Selected citations for CRT 0066101 include:

3 Citations: Showing 1 - 3

  1. Protein kinase D at the Golgi controls NLRP3 inflammasome activation.
    Authors: Zhang Et al.
    J Exp Med  2017;214:2671
  2. Protein kinase D and Gβγ subunits mediate agonist-evoked translocation of protease-activated receptor-2 from the Golgi apparatus to the plasma membrane.
    Authors: Jensen Et al.
    J.Biol.Chem.  2016;291:11285
  3. Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia.
    Authors: Liou Et al.
    Sci Rep  2015;6:6200

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